RON confers lapatinib resistance in HER2-positive breast cancer cells
文献类型：期刊论文
| 作者 | Wang, Quanren; Quan, Haitian ; Zhao, Jie; Xie, Chengying; Wang, Lei; Lou, Liguang
|
| 刊名 | CANCER LETTERS
 |
| 出版日期 | 2013-10-28 |
| 卷号 | 340期号:1页码:43-50 |
| 关键词 | RON Lapatinib resistance HER2 HER2-targeted agents |
| ISSN号 | 0304-3835 |
| DOI | 10.1016/j.canlet.2013.06.022 |
| 文献子类 | Article |
| 英文摘要 | Lapatinib-resistance is a major problem for HER2-positive breast cancer treatment. SK-BR-3-LR, a lapatinib-resistant cell clone, was established from HER2-positive SK-BR-3 breast cancer cells following chronic exposure to lapatinib. The PI3K/AKT signaling pathway was demonstrated to be resistant to HER2 inhibition in SK-BR-3-LR cells. However, both small-molecular Recepteur d'Origine Nantais (RON) inhibitors and RON-targeted small interfering RNA (siRNA) effectively restored lapatinib sensitivity in these cells by inhibiting PI3K/AKT activation. Our results demonstrate for the first time the important role of RON in mediating lapatinib resistance and suggest that RON-targeted therapy may become a novel, promising therapeutic strategy after the failure of lapatinib treatment in patients with HER2-positive breast cancer. (C) 2013 Elsevier Ireland Ltd. All rights reserved. |
| WOS关键词 | RECEPTOR TYROSINE KINASE ; STIMULATING PROTEIN-RECEPTOR ; C-MET ; INHIBITOR SELECTIVITY ; ALTERED EXPRESSION ; ANTITUMOR-ACTIVITY ; ACTIVATION ; POTENT ; SRC ; IDENTIFICATION |
| 资助项目 | National Natural Science Foundation of China[Y201181042] ; National Natural Science Foundation of China[81273546] ; National Science & Technology Major Project "Key New Drug Creation and Manufacturing Program", China[2013ZX09102008] ; National Science & Technology Major Project "Key New Drug Creation and Manufacturing Program", China[2013ZX09402102-001] |
| WOS研究方向 | Oncology |
| 语种 | 英语 |
| WOS记录号 | WOS:000325587500005 |
| 出版者 | ELSEVIER IRELAND LTD |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/277416]  |
| 专题 | 药理学第一研究室 |
| 通讯作者 | Lou, Liguang |
| 作者单位 | Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Quanren,Quan, Haitian,Zhao, Jie,et al. RON confers lapatinib resistance in HER2-positive breast cancer cells[J]. CANCER LETTERS,2013,340(1):43-50. |
| APA | Wang, Quanren,Quan, Haitian,Zhao, Jie,Xie, Chengying,Wang, Lei,&Lou, Liguang.(2013).RON confers lapatinib resistance in HER2-positive breast cancer cells.CANCER LETTERS,340(1),43-50. |
| MLA | Wang, Quanren,et al."RON confers lapatinib resistance in HER2-positive breast cancer cells".CANCER LETTERS 340.1(2013):43-50. |
入库方式： OAI收割
来源：上海药物研究所
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