The inhibition of metastasis and growth of breast cancer by blocking the NF-kappa B signaling pathway using bioreducible PEI-based/p65 shRNA complex nanoparticles
文献类型：期刊论文
| 作者 | Xiao, Jisheng2; Duan, Xiaopin2,3; Yin, Qi2 ; Miao, Zehong2; Yu, Haijun2; Chen, Chunying4; Zhang, Zhiwen2; Wang, Jun1; Li, Yaping2
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| 刊名 | BIOMATERIALS
 |
| 出版日期 | 2013-07 |
| 卷号 | 34期号:21页码:5381-5390 |
| 关键词 | Metastasis Bioreducible polymer shRNA Nanoparticles Breast cancer |
| ISSN号 | 0142-9612 |
| DOI | 10.1016/j.biomaterials.2013.03.084 |
| 文献子类 | Article |
| 英文摘要 | Metastasis is one of the greatest challenges in cancer treatment. In this study, a bioreducible polymer, Tween 85-s-s-polyethyleneimine 2K (TSP), was synthesized and used as a non-viral gene vector for p65 shRNA to block NF-kappa B signaling pathway, thereby inhibiting the growth and metastasis of breast cancer. The TSP/p65 shRNA complex nanoparticles (TSNs) could significantly down-regulate p65 expression in breast cancer cells due to the rapid degradation of TSP with prompt shRNA release, and consequently not only inhibit cell proliferation and invasion, but also induce cell apoptosis and disrupt the tube formation. Most importantly, TSNs showed high accumulation in tumor and almost completely inhibited the growth and metastasis of the breast cancer xenograft in nude mice induced by MDA-MB-435 cells. All these results indicated the promising of TSP as a non-viral gene vector to knock down p65 expression and inhibit the growth and metastasis of breast cancer. (C) 2013 Elsevier Ltd. All rights reserved. |
| WOS关键词 | CELL-LINES ; ANGIOGENESIS ; INVASION ; BLOCKADE ; CHEMORESISTANCE ; APOPTOSIS ; DELIVERY ; CASCADE |
| 资助项目 | National Basic Research Program of China[2010CB934000] ; National Basic Research Program of China[2012CB932502] ; National Basic Research Program of China[2013CB932503] ; National Basic Research Program of China[2013CB932704] ; National Natural Science Foundation of China[30925041] ; National Natural Science Foundation of China[81230029] ; Shanghai program[12nm0501300] |
| WOS研究方向 | Engineering ; Materials Science |
| 语种 | 英语 |
| WOS记录号 | WOS:000319630000047 |
| 出版者 | ELSEVIER SCI LTD |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/277576]  |
| 专题 | 药理学第一研究室 药物制剂研究中心 |
| 通讯作者 | Miao, Zehong |
| 作者单位 | 1.Univ Sci & Technol China, Sch Life Sci, Hefei 230026, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Mat Med, Ctr Pharmaceut, Shanghai 201203, Peoples R China; 3.Shenyang Pharmaceut Univ, Sch Pharm, Shenyang 110016, Peoples R China; 4.Natl Ctr Nanosci & Technol, Beijing 100190, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Xiao, Jisheng,Duan, Xiaopin,Yin, Qi,et al. The inhibition of metastasis and growth of breast cancer by blocking the NF-kappa B signaling pathway using bioreducible PEI-based/p65 shRNA complex nanoparticles[J]. BIOMATERIALS,2013,34(21):5381-5390. |
| APA | Xiao, Jisheng.,Duan, Xiaopin.,Yin, Qi.,Miao, Zehong.,Yu, Haijun.,...&Li, Yaping.(2013).The inhibition of metastasis and growth of breast cancer by blocking the NF-kappa B signaling pathway using bioreducible PEI-based/p65 shRNA complex nanoparticles.BIOMATERIALS,34(21),5381-5390. |
| MLA | Xiao, Jisheng,et al."The inhibition of metastasis and growth of breast cancer by blocking the NF-kappa B signaling pathway using bioreducible PEI-based/p65 shRNA complex nanoparticles".BIOMATERIALS 34.21(2013):5381-5390. |
入库方式： OAI收割
来源：上海药物研究所
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