Oligodeoxyribonucleotides derived from salmon sperm DNA: An alternative to defibrotide
文献类型：期刊论文
| 作者 | Hui, Chang-Ye2; Guo, Yan3; Zhang, Xi1; Shao, Jian-Hua4; Yang, Xue-Qin2; Zhang, Wen2 |
| 刊名 | BIOLOGICALS
 |
| 出版日期 | 2013-05 |
| 卷号 | 41期号:3页码:190-196 |
| 关键词 | Defibrotide Oligonucleotide Salmon sperm DNA Depolymerization |
| ISSN号 | 1045-1056 |
| DOI | 10.1016/j.biologicals.2012.12.003 |
| 文献子类 | Article |
| 英文摘要 | Defibrotide is a single-stranded nucleic acid polymer originally derived from porcine mucosa. Cheap salmon sperm DNA is commercially available and widely used in drug production. In this study, oligodeoxyribonucleotides were successfully obtained from the controlled depolymerization of salmon sperm DNA. The obtained product shared similar chemical and biological properties with defibrotide produced by Gentium SpA, Italy. It was also found that oligodeoxyribonucleotides derived from non-mammalian origins could also directly stimulate tissue plasminogen activator (t-PA) release from cultured human endothelial cells, and enhance fibrinolytic activity in the rabbit. (C) 2013 The International Alliance for Biological Standardization. Published by Elsevier Ltd. All rights reserved. |
| WOS关键词 | PROFIBRINOLYTIC ACTIVITY ; FIBRINOLYTIC-ACTIVITY ; ENDOTHELIAL-CELLS ; PLASMIN ACTIVITY ; TRIAL |
| WOS研究方向 | Biochemistry & Molecular Biology ; Biotechnology & Applied Microbiology ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000319955300010 |
| 出版者 | ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/277630]  |
| 专题 | 药理学第一研究室 |
| 通讯作者 | Hui, Chang-Ye |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 200031, Peoples R China; 2.Shenzhen Prevent & Treatment Ctr Occupat Dis, Shenzhen 518001, Guangdong, Peoples R China; 3.Chinese Acad Sci, Shenzhen Inst Adv Technol, Shenzhen, Peoples R China; 4.Yangzhou Univ, Coll Biosci & Biotechnol, Yangzhou, Peoples R China |
| 推荐引用方式 GB/T 7714 | Hui, Chang-Ye,Guo, Yan,Zhang, Xi,et al. Oligodeoxyribonucleotides derived from salmon sperm DNA: An alternative to defibrotide[J]. BIOLOGICALS,2013,41(3):190-196. |
| APA | Hui, Chang-Ye,Guo, Yan,Zhang, Xi,Shao, Jian-Hua,Yang, Xue-Qin,&Zhang, Wen.(2013).Oligodeoxyribonucleotides derived from salmon sperm DNA: An alternative to defibrotide.BIOLOGICALS,41(3),190-196. |
| MLA | Hui, Chang-Ye,et al."Oligodeoxyribonucleotides derived from salmon sperm DNA: An alternative to defibrotide".BIOLOGICALS 41.3(2013):190-196. |
入库方式： OAI收割
来源：上海药物研究所
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