Critical role of transmethylation in TLR signaling and systemic lupus erythematosus
文献类型：期刊论文
| 作者 | Tardif, Virginie2; Manenkova, Yulia4; Berger, Michael3; Hoebe, Kasper2; Zuo, Jian-Ping1 ; Yuan, Chong4; Kono, Dwight H.2; Theofilopoulos, Argyrios N.2; Lawson, Brian R.2
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| 刊名 | CLINICAL IMMUNOLOGY
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| 出版日期 | 2013-05 |
| 卷号 | 147期号:2页码:133-143 |
| 关键词 | Systemic lupus erythematosus Transmethylation S-adenosyl-L-homocysteine hydrolase Toll-like receptors Lymphocytes |
| ISSN号 | 1521-6616 |
| DOI | 10.1016/j.clim.2013.02.018 |
| 文献子类 | Article |
| 英文摘要 | Post-translational protein modifications can play a significant role in immune cell signaling. Recently, we showed that inhibition of transmethylation curtails experimental autoimmune encephalomyelitis, notably by reducing T cell receptor (TCR)-induced activation of CD4(+) T cells. Here, we demonstrate that transmethylation inhibition by a reversible S-adenosyl-L-homocysteine hydrolase inhibitor (DZ2002) led to immunosuppression by reducing TLR-, B cell receptor (BCR)- and TCR-induced activation of immune cells, most likely by blocking NF-kappa B activity. Moreover, prophylactic treatment with DZ2002 prevented lupus-like disease from developing in both BXSB and MRL-Fas(lpr) mouse models. DZ2002 treatment initiated during active disease significantly improved outcomes in both in vivo models, suggesting methylation inhibition as a novel approach for the treatment of autoimmune/inflammatory diseases. (C) 2013 Elsevier Inc. All rights reserved. |
| WOS关键词 | L-HOMOCYSTEINE HYDROLASE ; T-CELL-ACTIVATION ; PROTEIN ARGININE METHYLATION ; KAPPA-B ACTIVATION ; MURINE LUPUS ; S-ADENOSYLMETHIONINE ; MACROPHAGE ACTIVATION ; GENE-EXPRESSION ; NUCLEIC-ACID ; IFN-GAMMA |
| 资助项目 | NIH[00000000] |
| WOS研究方向 | Immunology |
| 语种 | 英语 |
| WOS记录号 | WOS:000318328900009 |
| 出版者 | ACADEMIC PRESS INC ELSEVIER SCIENCE |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/277640]  |
| 专题 | 药理学第一研究室 |
| 通讯作者 | Lawson, Brian R. |
| 作者单位 | 1.Shanghai Inst Mat Med, Shanghai, Peoples R China; 2.Scripps Res Inst, Dept Immunol & Microbial Sci, La Jolla, CA 92037 USA; 3.Scripps Res Inst, Dept Genet, La Jolla, CA 92037 USA; 4.Gen Atom, Diazyme Div, San Diego, CA USA |
| 推荐引用方式 GB/T 7714 | Tardif, Virginie,Manenkova, Yulia,Berger, Michael,et al. Critical role of transmethylation in TLR signaling and systemic lupus erythematosus[J]. CLINICAL IMMUNOLOGY,2013,147(2):133-143. |
| APA | Tardif, Virginie.,Manenkova, Yulia.,Berger, Michael.,Hoebe, Kasper.,Zuo, Jian-Ping.,...&Lawson, Brian R..(2013).Critical role of transmethylation in TLR signaling and systemic lupus erythematosus.CLINICAL IMMUNOLOGY,147(2),133-143. |
| MLA | Tardif, Virginie,et al."Critical role of transmethylation in TLR signaling and systemic lupus erythematosus".CLINICAL IMMUNOLOGY 147.2(2013):133-143. |
入库方式： OAI收割
来源：上海药物研究所
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