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Curcumin Induces Cell Death and Restores Tamoxifen Sensitivity in the Antiestrogen-Resistant Breast Cancer Cell Lines MCF-7/LCC2 and MCF-7/LCC9

文献类型：期刊论文

作者Jiang, Min2; Huang, Ou2; Zhang, Xi2; Xie, Zuoquan1; Shen, Aijun1; Liu, Hongchun1; Geng, Meiyu1; Shen, Kunwei2
刊名MOLECULES
出版日期2013-01
卷号18期号:1页码:701-720
关键词curcumin endocrine resistance tamoxifen NF-kappa B Src/FAK Akt/mTOR EZH2 cyclin D1 c-Myc
ISSN号1420-3049
DOI10.3390/molecules18010701
文献子类Article
英文摘要Curcumin, a principal component of turmeric (Curcuma longa), has potential therapeutic activities against breast cancer through multiple signaling pathways. Increasing evidence indicates that curcumin reverses chemo-resistance and sensitizes cancer cells to chemotherapy and targeted therapy in breast cancer. To date, few studies have explored its potential antiproliferation effects and resistance reversal in antiestrogen-resistant breast cancer. In this study, we therefore investigated the efficacy of curcumin alone and in combination with tamoxifen in the established antiestrogen-resistant breast cancer cell lines MCF-7/LCC2 and MCF-7/LCC9. We discovered that curcumin treatment displayed anti-proliferative and pro-apoptotic activities and induced cell cycle arrest at G2/M phase. Of note, the combination of curcumin and tamoxifen resulted in a synergistic survival inhibition in MCF-7/LCC2 and MCF-7/LCC9 cells. Moreover, we found that curcumin targeted multiple signals involved in growth maintenance and resistance acquisition in endocrine resistant cells. In our cell models, curcumin could suppress expression of pro-growth and anti-apoptosis molecules, induce inactivation of NF-kappa B, Src and Akt/mTOR pathways and downregulate the key epigenetic modifier EZH2. The above findings suggested that curcumin alone and combinations of curcumin with endocrine therapy may be of therapeutic benefit for endocrine-resistant breast cancer.
WOS关键词NF-KAPPA-B ; ESTROGEN-RECEPTOR ; CLINICAL-IMPLICATIONS ; ENDOCRINE RESISTANCE ; GENE-EXPRESSION ; GROWTH-FACTOR ; IN-VITRO ; PATHWAY ; INHIBITION ; EZH2
资助项目National Natured Science Foundation of China[81172520]
WOS研究方向Biochemistry & Molecular Biology ; Chemistry
语种英语
WOS记录号WOS:000314032900044
出版者MDPI
源URL[http://119.78.100.183/handle/2S10ELR8/277824]  
专题药理学第一研究室
通讯作者Geng, Meiyu
作者单位1.Chinese Acad Sci, Div Antitumor Pharmacol, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China
2.Shanghai Jiao Tong Univ, Sch Med, Ruijin Hosp, Comprehens Breast Hlth Ctr, Shanghai 200025, Peoples R China;
推荐引用方式
GB/T 7714		 Jiang, Min,Huang, Ou,Zhang, Xi,et al. Curcumin Induces Cell Death and Restores Tamoxifen Sensitivity in the Antiestrogen-Resistant Breast Cancer Cell Lines MCF-7/LCC2 and MCF-7/LCC9[J]. MOLECULES,2013,18(1):701-720.
APA Jiang, Min.,Huang, Ou.,Zhang, Xi.,Xie, Zuoquan.,Shen, Aijun.,...&Shen, Kunwei.(2013).Curcumin Induces Cell Death and Restores Tamoxifen Sensitivity in the Antiestrogen-Resistant Breast Cancer Cell Lines MCF-7/LCC2 and MCF-7/LCC9.MOLECULES,18(1),701-720.
MLA Jiang, Min,et al."Curcumin Induces Cell Death and Restores Tamoxifen Sensitivity in the Antiestrogen-Resistant Breast Cancer Cell Lines MCF-7/LCC2 and MCF-7/LCC9".MOLECULES 18.1(2013):701-720.

入库方式： OAI收割

来源：上海药物研究所

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