A novel water-soluble beta-D-glucan isolated from the spores of Ganoderma lucidum
文献类型：期刊论文
| 作者 | Dong, Qun1; Wang, Ying1; Shi, Lei1; Yao, Jian1; Li, Jie1; Ma, Fangli2; Ding, Kan1
|
| 刊名 | CARBOHYDRATE RESEARCH
 |
| 出版日期 | 2012-05-15 |
| 卷号 | 353页码:100-105 |
| 关键词 | Ganoderma lucidum beta-(1 -> 6)-Glucan Polysaccharide Structure |
| ISSN号 | 0008-6215 |
| DOI | 10.1016/j.carres.2012.02.029 |
| 文献子类 | Article |
| 英文摘要 | Ganoderma lucidum is an edible and medicinal mushroom used widely in East Asia. In recent years, its spores have been used as a supplement in combination with other forms of antitumor therapies. The cell wall of Ganoderma lucidum spores contains a high amount of polysaccharides. In this study, a neutral polysaccharide, GLSA50-1B, was isolated from sporoderm-broken spores of Ganoderma lucidum, by hot-water extraction, graded ethanol precipitation, anion-exchange chromatography, and gel permeation chromatography. Using sugar compositional analysis, methylation analysis, partial acid hydrolysis, acetolysis, and NMR and ESI-MS spectroscopy, GLSA50-1B was elucidated to be a novel beta-D-glucan featured by a 1,6-linked beta-D-Glcp backbone with different length of branches consisting of terminal and 1,4-linked Glcp residues, attached to O-4 of alternative Glc residues in the backbone. (C) 2012 Elsevier Ltd. All rights reserved. |
| WOS关键词 | STRUCTURAL-CHARACTERIZATION ; FR. KARST ; POLYSACCHARIDE ; CELLS ; CYTOKINES ; FEATURES ; VEGF ; MICE |
| 资助项目 | National High Technology Project (863)[2007AA10Z341] ; Key New Drug Creation and Manufacturing Program[2009ZX09501-011] ; Key New Drug Creation and Manufacturing Program[2009ZX09103-071] ; Key New Drug Creation and Manufacturing Program[2009ZX09301-001] |
| WOS研究方向 | Biochemistry & Molecular Biology ; Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000304053900014 |
| 出版者 | ELSEVIER SCI LTD |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/278076]  |
| 专题 | 药理学第三研究室 |
| 通讯作者 | Dong, Qun |
| 作者单位 | 1.Chinese Acad Sci & Infinitus, Shanghai Inst Mat Med, Glycobiol & Glycochem Lab, Shanghai 201203, Peoples R China; 2.Lee Kum Kee Hlth Prod Grp Ltd, Hong Kong, Hong Kong, Peoples R China |
| 推荐引用方式 GB/T 7714 | Dong, Qun,Wang, Ying,Shi, Lei,et al. A novel water-soluble beta-D-glucan isolated from the spores of Ganoderma lucidum[J]. CARBOHYDRATE RESEARCH,2012,353:100-105. |
| APA | Dong, Qun.,Wang, Ying.,Shi, Lei.,Yao, Jian.,Li, Jie.,...&Ding, Kan.(2012).A novel water-soluble beta-D-glucan isolated from the spores of Ganoderma lucidum.CARBOHYDRATE RESEARCH,353,100-105. |
| MLA | Dong, Qun,et al."A novel water-soluble beta-D-glucan isolated from the spores of Ganoderma lucidum".CARBOHYDRATE RESEARCH 353(2012):100-105. |
入库方式： OAI收割
来源：上海药物研究所
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