Cycloartane and Friedelane Triterpenoids from the Leaves of Caloncoba glauca and Their Evaluation for Inhibition of 11 beta-Hydroxysteroid Dehydrogenases
文献类型：期刊论文
| 作者 | Mpetga, James D. Simo1,2; Shen, Yu3; Tane, Pierre2; Li, Shi-Fei1; He, Hong-Ping1; Wabo, Hippolyte K.2; Tene, Mathieu2; Leng, Ying3 ; Hao, Xiao-Jiang1
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| 刊名 | JOURNAL OF NATURAL PRODUCTS
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| 出版日期 | 2012-04 |
| 卷号 | 75期号:4页码:599-604 |
| ISSN号 | 0163-3864 |
| DOI | 10.1021/np200831c |
| 文献子类 | Article |
| 英文摘要 | Five new triterpenoids, caloncobic acids A and B (1 and 2), caloncobalactones A and B (3 and 4), and glaucalactone (5), along with the known compounds 3 beta,21 beta-dihydroxy-30-nor-(D:A)-friedo-olean-20(29)-en-27-oic acid (6) and acetyltrichadenic acid B (7), were isolated from the leaves of Caloncoba glauca. The structures of 1-5 were elucidated using spectroscopic methods. Compounds 1-7 were evaluated for their inhibitory activities against two isozymes of 11 beta-hydroxysteroid dehydrogenase (11 beta-HSD1 and 11 beta-HSD2). Compounds 1 and 2 exhibited strong inhibitory activities against mouse (EC50 132 and 13 nM) and human (EC50 105 and 72 nM) 11 beta-HSD1. |
| WOS关键词 | ELLIPTICA HAND-MAZZ ; STEM BARK ; LYOFOLIC ACID ; CONSTITUENTS ; GLYCOSIDES ; GLUCOSIDE |
| 资助项目 | University of Dschang[00000000] ; Chinese Academy of Sciences (CAS)[00000000] ; Academy of Sciences for the Developing World (TWAS)[00000000] |
| WOS研究方向 | Plant Sciences ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000303220500012 |
| 出版者 | AMER CHEMICAL SOC |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/278128]  |
| 专题 | 药理学第一研究室 |
| 通讯作者 | Leng, Ying |
| 作者单位 | 1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650201, Peoples R China; 2.Univ Dschang, Dept Chem, Lab Nat Prod Chem, Dschang, Cameroon 3.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Mpetga, James D. Simo,Shen, Yu,Tane, Pierre,et al. Cycloartane and Friedelane Triterpenoids from the Leaves of Caloncoba glauca and Their Evaluation for Inhibition of 11 beta-Hydroxysteroid Dehydrogenases[J]. JOURNAL OF NATURAL PRODUCTS,2012,75(4):599-604. |
| APA | Mpetga, James D. Simo.,Shen, Yu.,Tane, Pierre.,Li, Shi-Fei.,He, Hong-Ping.,...&Hao, Xiao-Jiang.(2012).Cycloartane and Friedelane Triterpenoids from the Leaves of Caloncoba glauca and Their Evaluation for Inhibition of 11 beta-Hydroxysteroid Dehydrogenases.JOURNAL OF NATURAL PRODUCTS,75(4),599-604. |
| MLA | Mpetga, James D. Simo,et al."Cycloartane and Friedelane Triterpenoids from the Leaves of Caloncoba glauca and Their Evaluation for Inhibition of 11 beta-Hydroxysteroid Dehydrogenases".JOURNAL OF NATURAL PRODUCTS 75.4(2012):599-604. |
入库方式： OAI收割
来源：上海药物研究所
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