Inhibition of GPR40 protects MIN6 beta cells from palmitate-induced ER stress and apoptosis
文献类型：期刊论文
| 作者 | Wu, Jinwei; Sun, Peng; Zhang, Xiaodong; Liu, Hong ; Jiang, Hualiang; Zhu, Weiliang; Wang, Heyao
|
| 刊名 | JOURNAL OF CELLULAR BIOCHEMISTRY
 |
| 出版日期 | 2012-04 |
| 卷号 | 113期号:4页码:1152-1158 |
| 关键词 | GPR40 ANTAGONIST MIN6 ss CELLS PALMITATE ENDOPLASMIC RETICULUM STRESS APOPTOSIS |
| ISSN号 | 0730-2312 |
| DOI | 10.1002/jcb.23450 |
| 文献子类 | Article |
| 英文摘要 | Chronic exposure to elevated concentration of free fatty acids (FFA) has been verified to induce endoplasmic reticulum (ER) stress, which leads to pancreatic beta-cell apoptosis. As one of the medium and long chain FFA receptors, GPR40 is highly expressed in pancreatic beta cells, mediates both acute and chronic effects of FFA on beta-cell function, but the role of GPR40 in FFA-induced beta-cell apoptosis remains unclear. In this study, we investigated the possible effects of GPR40 in palmitate-induced MIN6 beta-cell apoptosis, and found that DC260126, a novel small molecular antagonist of GPR40, could protect MIN6 beta cells from palmitate-induced ER stress and apoptosis. Similar results were observed in GPR40-deficient MIN6 cells, indicating that palmitate-induced beta-cell apoptosis is at least partially dependent on ER stress pathway via GRP40. J. Cell. Biochem. 113: 11521158, 2012. (c) 2011 Wiley Periodicals, Inc. |
| WOS关键词 | ENDOPLASMIC-RETICULUM STRESS ; FATTY-ACID RECEPTOR ; INSULIN-SECRETION ; DYSFUNCTION ; MECHANISMS ; DEATH ; ANTAGONIST ; RESISTANCE ; INCREASE ; IMPROVES |
| 资助项目 | National Natural Science Foundation of China[81073681] ; National Science and Technology Major Project "Key New Drug Creation and Manufacturing Program"[2009ZX09301-001] ; National High Technology Research and Development Program of China (863 Program)[2007AA02Z301] ; Shanghai Science and Technology Innovation Program[08431900800] |
| WOS研究方向 | Biochemistry & Molecular Biology ; Cell Biology |
| 语种 | 英语 |
| WOS记录号 | WOS:000300719000008 |
| 出版者 | WILEY |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/278138]  |
| 专题 | 药理学第三研究室 |
| 通讯作者 | Wang, Heyao |
| 作者单位 | Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wu, Jinwei,Sun, Peng,Zhang, Xiaodong,et al. Inhibition of GPR40 protects MIN6 beta cells from palmitate-induced ER stress and apoptosis[J]. JOURNAL OF CELLULAR BIOCHEMISTRY,2012,113(4):1152-1158. |
| APA | Wu, Jinwei.,Sun, Peng.,Zhang, Xiaodong.,Liu, Hong.,Jiang, Hualiang.,...&Wang, Heyao.(2012).Inhibition of GPR40 protects MIN6 beta cells from palmitate-induced ER stress and apoptosis.JOURNAL OF CELLULAR BIOCHEMISTRY,113(4),1152-1158. |
| MLA | Wu, Jinwei,et al."Inhibition of GPR40 protects MIN6 beta cells from palmitate-induced ER stress and apoptosis".JOURNAL OF CELLULAR BIOCHEMISTRY 113.4(2012):1152-1158. |
入库方式： OAI收割
来源：上海药物研究所
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