Synthesis and cytotoxicity of diam(m)ineplatinum(II) complexes with 2,2-bis(hydroxymethyl)malonate as the leaving group
文献类型：期刊论文
| 作者 | Xing, Yingjuan; Lou, Liguang ; Chen, Xizhu; Ye, Qingsong; Xu, Yongping; Xie, Chengying; Jiang, Jing; Liu, Weiping
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| 刊名 | BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
 |
| 出版日期 | 2012-03-15 |
| 卷号 | 22期号:6页码:2239-2241 |
| 关键词 | Platinum 2,2-bis(Hydroxymethyl)malonate Synthesis Anticancer activity |
| ISSN号 | 0960-894X |
| DOI | 10.1016/j.bmcl.2012.01.091 |
| 文献子类 | Article |
| 英文摘要 | Six diam(m)ineplatinum(II) complexes with 2,2-bis(hydroxymethyl)malonate as the leaving group were synthesized and characterized by elemental analysis, FAB-MS, FT-IR, H-1 and C-13 NMR along with a single crystal X-ray diffraction for a representative compound. All the complexes were evaluated for the cytotoxicity against human cancer cell lines A549/ATCC, HT-29, SGC-7901. The activity is related to the nature of the am(m)ine ligand. cis-[Pt(II)(1R,2R-Diaminocyclohexane).2,2-bis(hydroxymethyl) malonate] (complex 5) exhibits the greatest activity among those six complexes, and is even more active than its parent compound oxaliplatin. LD50 was found to be 115 mg/kg by iv administration to ICR mice, much larger than that of oxaliplatin (LD50 = 19 mg/kg). (C) 2012 Elsevier Ltd. All rights reserved. |
| WOS关键词 | TOXICITY ; ANALOG |
| 资助项目 | National Natural Science Foundation of China[21161010] ; Yunnan Provincial Science Foundation of China[2008CC020] |
| WOS研究方向 | Pharmacology & Pharmacy ; Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000301285500022 |
| 出版者 | PERGAMON-ELSEVIER SCIENCE LTD |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/278151]  |
| 专题 | 药理学第一研究室 |
| 作者单位 | Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Xing, Yingjuan,Lou, Liguang,Chen, Xizhu,et al. Synthesis and cytotoxicity of diam(m)ineplatinum(II) complexes with 2,2-bis(hydroxymethyl)malonate as the leaving group[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2012,22(6):2239-2241. |
| APA | Xing, Yingjuan.,Lou, Liguang.,Chen, Xizhu.,Ye, Qingsong.,Xu, Yongping.,...&Liu, Weiping.(2012).Synthesis and cytotoxicity of diam(m)ineplatinum(II) complexes with 2,2-bis(hydroxymethyl)malonate as the leaving group.BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,22(6),2239-2241. |
| MLA | Xing, Yingjuan,et al."Synthesis and cytotoxicity of diam(m)ineplatinum(II) complexes with 2,2-bis(hydroxymethyl)malonate as the leaving group".BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 22.6(2012):2239-2241. |
入库方式： OAI收割
来源：上海药物研究所
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