Pseudoferic acids A-C, three novel triterpenoids from the root bark of Pseudolarix kaempferi
文献类型：期刊论文
| 作者 | Wu, Xing-De1,3; He, Juan1; Shen, Yu4; Dong, Liao-Bin1,3; Pan, Zheng-Hong1; Xu, Gang1; Gong, Xun1; Song, Liu-Dong2; Leng, Ying4 ; Li, Yan1
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| 刊名 | TETRAHEDRON LETTERS
 |
| 出版日期 | 2012-02-15 |
| 卷号 | 53期号:7页码:800-803 |
| 关键词 | Pseudolarix kaempferi Triterpenoids 11 beta-HSD1 inhibitory activity |
| ISSN号 | 0040-4039 |
| DOI | 10.1016/j.tetlet.2011.12.004 |
| 文献子类 | Article |
| 英文摘要 | Three novel triterpenoids, pseudoferic acids A and B (1 and 2) possessed a unique 16,24-cyclo-26-norlanostane skeleton, and pseudoferic acid C (3) featured a cis-fused D/E-ring system, were isolated from the root bark of Pseudolarix kaempferi. Their structures were elucidated on the basis of extensive spectroscopic analysis. Compounds 2 and 3 exhibited weak inhibitory activities against 110-HSD1 (110-hydroxysteroid dehydrogenase 1) with IC50 values of 0.44 (mouse 11 beta-HSD1) and 0.75 mu M (human 11 beta-HSD1), respectively. (C) 2011 Elsevier Ltd. All rights reserved. |
| WOS关键词 | TU-JIN-PI ; CYCLOARTENOL SYNTHASE ; CONSTITUENTS ; STEREOCHEMISTRY ; DITERPENOIDS ; ANGIOGENESIS ; LANOSTEROL |
| 资助项目 | National Basic Research Program of China (973 Program)[2009CB522303] ; National Basic Research Program of China (973 Program)[2011CB915503] ; National Natural Science Foundation of China[90813004] ; National Natural Science Foundation of China[U0932602] ; Chinese Academy of sciences[2009311211011] ; Chinese Academy of sciences[2009312311024] ; State Key Laboratory of Phytochemistry and Plant Resources in West China[P2010-ZZ05] |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000300518900019 |
| 出版者 | PERGAMON-ELSEVIER SCIENCE LTD |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/278181]  |
| 专题 | 药理学第一研究室 |
| 通讯作者 | Song, Liu-Dong |
| 作者单位 | 1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650201, Peoples R China; 2.Kunming Med Univ, Coll Pharmacol, Kunming 650031, Peoples R China; 3.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China; 4.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wu, Xing-De,He, Juan,Shen, Yu,et al. Pseudoferic acids A-C, three novel triterpenoids from the root bark of Pseudolarix kaempferi[J]. TETRAHEDRON LETTERS,2012,53(7):800-803. |
| APA | Wu, Xing-De.,He, Juan.,Shen, Yu.,Dong, Liao-Bin.,Pan, Zheng-Hong.,...&Zhao, Qin-Shi.(2012).Pseudoferic acids A-C, three novel triterpenoids from the root bark of Pseudolarix kaempferi.TETRAHEDRON LETTERS,53(7),800-803. |
| MLA | Wu, Xing-De,et al."Pseudoferic acids A-C, three novel triterpenoids from the root bark of Pseudolarix kaempferi".TETRAHEDRON LETTERS 53.7(2012):800-803. |
入库方式： OAI收割
来源：上海药物研究所
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