Cyclopeptide Alkaloids from Ziziphus apetala
文献类型：期刊论文
| 作者 | Han, Jing1,2; Ji, Chang-Jiu1,2; He, Wen-Jun2; Shen, Yu1,3; Leng, Ying3 ; Xu, Wen-Yan2; Fan, Jun-Ting2; Zeng, Guang-Zhi2; Kong, Ling-Dong4; Tan, Ning-Hua2
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| 刊名 | JOURNAL OF NATURAL PRODUCTS
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| 出版日期 | 2011-12 |
| 卷号 | 74期号:12页码:2571-2575 |
| ISSN号 | 0163-3864 |
| DOI | 10.1021/np200755t |
| 文献子类 | Article |
| 英文摘要 | Six novel Ia(3)-type cyclopeptide alkaloids (1-6) were isolated from stems of Ziziphus apetala. Compound 5 and the known compounds mauritine A (7) and mauritine F (8) were isolated from the roots. Their structures were determined by spectroscopic analyses and chemical methods. The total alkaloids from the roots and the isolated cyclopeptide alkaloids were tested for antidepressant behavior on mice, cytotoxicity, and 11 beta-hydroxysteroid dehydrogenase (11 beta-HSD) inhibition in vitro. Only mauritine A (7) showed inhibitory activity on 11 beta-HSD1, with IC50 values of 52.0 (human) and 31.2 mu g/mL (mouse). |
| 资助项目 | National Natural Science Foundation of China[30725048] ; National Natural Science Foundation of China[91013002] ; National Natural Science Foundation of China[U1032602] ; National New Drug Innovation Major Project of China[2011ZX09307-002-02] ; National Basic Research Program of China[2009CB522300] ; Chinese Academy of Sciences[KSCX2-YW-R-177] |
| WOS研究方向 | Plant Sciences ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000298315800011 |
| 出版者 | AMER CHEMICAL SOC |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/278313]  |
| 专题 | 药理学第一研究室 |
| 通讯作者 | Tan, Ning-Hua |
| 作者单位 | 1.Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China 2.Chinese Acad Sci, State Key Lab Phytochem & Plant Resources W China, Kunming Inst Bot, Kunming 650201, Yunnan, Peoples R China; 3.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China; 4.Nanjing Univ, Nanjing 210093, Jiangsu, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Han, Jing,Ji, Chang-Jiu,He, Wen-Jun,et al. Cyclopeptide Alkaloids from Ziziphus apetala[J]. JOURNAL OF NATURAL PRODUCTS,2011,74(12):2571-2575. |
| APA | Han, Jing.,Ji, Chang-Jiu.,He, Wen-Jun.,Shen, Yu.,Leng, Ying.,...&Tan, Ning-Hua.(2011).Cyclopeptide Alkaloids from Ziziphus apetala.JOURNAL OF NATURAL PRODUCTS,74(12),2571-2575. |
| MLA | Han, Jing,et al."Cyclopeptide Alkaloids from Ziziphus apetala".JOURNAL OF NATURAL PRODUCTS 74.12(2011):2571-2575. |
入库方式： OAI收割
来源：上海药物研究所
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