Mitochondrial Electron Transport Chain Complex III Is Required for Antimycin A to Inhibit Autophagy
文献类型：期刊论文
| 作者 | Ma, Xiuquan2; Jin, Mingzhi2; Cai, Yu2; Xia, Hongguang2; Long, Kai2; Liu, Junli2; Yu, Qiang1 ; Yuan, Junying2,3
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| 刊名 | CHEMISTRY & BIOLOGY
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| 出版日期 | 2011-11-23 |
| 卷号 | 18期号:11页码:1474-1481 |
| ISSN号 | 1074-5521 |
| DOI | 10.1016/j.chembiol.2011.08.009 |
| 文献子类 | Article |
| 英文摘要 | Autophagy is a cellular lysosome-dependent catabolic mechanism mediating the turnover of intracellular organelles and long-lived proteins. We show that antimycin A, a known inhibitor of mETC complex III, can inhibit autophagy. A structural and functional study shows that four close analogs of antimycin A that have no effect on mitochondria inhibition also do not inhibit autophagy, whereas myxothiazol, another mETC complex III inhibitor with unrelated structure to antimycin A, inhibits autophagy. Additionally, antimycin A and myxothiazol cannot inhibit autophagy in mtDNA-depleted H4 and mtDNA-depleted He La cells. These data suggest that antimycin A inhibits autophagy through its inhibitory activity on mETC complex III. Our data suggest that mETC complex III may have a role in mediating autophagy induction. |
| WOS关键词 | ENDOPLASMIC-RETICULUM ; REACTIVE OXYGEN ; SACCHAROMYCES-CEREVISIAE ; CELL-DEATH ; GOLGI ; MEMBRANES ; APOPTOSIS ; REVEALS ; DISEASE ; ADIPOGENESIS |
| 资助项目 | NIH, US[00000000] ; National Institute on Aging (US)[PO1 AG027916] ; National Natural Science Foundation of China[31129004] ; National Natural Science Foundation of China[31000619] ; Shanghai Science and Technology Research Grants[08DZ1971403] ; Shanghai Science and Technology Research Grants[09JC1416700] ; China National Science & Technology Key Project[2012CB910704] |
| WOS研究方向 | Biochemistry & Molecular Biology |
| 语种 | 英语 |
| WOS记录号 | WOS:000297603600019 |
| 出版者 | CELL PRESS |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/278332]  |
| 专题 | 药理学第一研究室 |
| 通讯作者 | Yu, Qiang |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, Dept Pharmacol, Shanghai 201203, Peoples R China; 2.Chinese Acad Sci, Shanghai Inst Organ Chem, State Key Lab Bioorgan & Nat Prod Chem, Shanghai 200032, Peoples R China; 3.Harvard Univ, Sch Med, Dept Cell Biol, Boston, MA 02115 USA |
| 推荐引用方式 GB/T 7714 | Ma, Xiuquan,Jin, Mingzhi,Cai, Yu,et al. Mitochondrial Electron Transport Chain Complex III Is Required for Antimycin A to Inhibit Autophagy[J]. CHEMISTRY & BIOLOGY,2011,18(11):1474-1481. |
| APA | Ma, Xiuquan.,Jin, Mingzhi.,Cai, Yu.,Xia, Hongguang.,Long, Kai.,...&Yuan, Junying.(2011).Mitochondrial Electron Transport Chain Complex III Is Required for Antimycin A to Inhibit Autophagy.CHEMISTRY & BIOLOGY,18(11),1474-1481. |
| MLA | Ma, Xiuquan,et al."Mitochondrial Electron Transport Chain Complex III Is Required for Antimycin A to Inhibit Autophagy".CHEMISTRY & BIOLOGY 18.11(2011):1474-1481. |
入库方式： OAI收割
来源：上海药物研究所
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