Chemical Constituents and Their Bioactivities of "Tongling White Ginger" (Zingiber officinale)
文献类型：期刊论文
| 作者 | Feng, Tao1; Su, Jia1; Ding, Zhi-Hui1; Zheng, Yong-Tang3,4; Li, Yan1; Leng, Ying2 ; Liu, Ji-Kai1
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| 刊名 | JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
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| 出版日期 | 2011-11-09 |
| 卷号 | 59期号:21页码:11690-11695 |
| 关键词 | Zingiber officinale Tongling White Ginger gingerdione dimers gingerol derivatives 11 beta-HSD |
| ISSN号 | 0021-8561 |
| DOI | 10.1021/jf202544w |
| 文献子类 | Article |
| 英文摘要 | Gingerols and their corresponding dehydration products shogaols were considered as the active principles of ginger, the rhizome of the plant Zingiber officinale, for its antioxidant, ant-inflammatory, and antitumor activities Ginger (Z. officinale) has been cultivated for thousands of years as a spice and for medicinal purposes in China. Tongling (Anhui province, China) has traditionally been regarded as an ideal cultivation place "Tongling White Ginger" enjoys a reputation for being one of the top gingers in China for its thin white peel, tender flesh, rich juice, and flavor In this study, we have isolated and identified two novel gingerdione dimers, bisgingerdiones A (1) and B (2), two new gingerol derivatives, (5R)-5-acetoxy-1,7-bis(4-hydroxy-3-methoxyphenyl)heptan-3-one (3) and methyl (Z)-neral acetal-[6]-gingerdiol (4), and 38 known compounds (5-42) from rhizomes of Zingiber officinale collected from Tongling, China. Their structures were elucidated by means of spectroscopic methods Compounds 1-4 showed weak cytotoxic and anti-HIV-1 activities Compounds 6, 8, and 26 showed inhibitory activities against human and mouse 11 beta-HSD1 (11 beta-hydroxysteroid dehydrogenases) with IC50 values between 1 09 and 1 30 mu M. |
| WOS关键词 | DIARYLHEPTANOIDS ; PROLIFERATION ; RHIZOMES ; CELLS |
| 资助项目 | National Basic Research Program of China (973 Program)[2009CB522300] ; National Natural Sciences Foundation of China[30830113] ; MOST[2009ZX09501-029] |
| WOS研究方向 | Agriculture ; Chemistry ; Food Science & Technology |
| 语种 | 英语 |
| WOS记录号 | WOS:000296312000041 |
| 出版者 | AMER CHEMICAL SOC |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/278338]  |
| 专题 | 药理学第一研究室 |
| 通讯作者 | Liu, Ji-Kai |
| 作者单位 | 1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Peoples R China; 2.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 200031, Peoples R China; 3.Chinese Acad Sci, Kunming Inst Zool, Key Lab Anim Models & Human Dis Mech, Kunming 650223, Peoples R China; 4.Chinese Acad Sci, Kunming Inst Bot, Lab Mol Immunopharmacol, Kunming 650204, Peoples R China |
| 推荐引用方式 GB/T 7714 | Feng, Tao,Su, Jia,Ding, Zhi-Hui,et al. Chemical Constituents and Their Bioactivities of "Tongling White Ginger" (Zingiber officinale)[J]. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,2011,59(21):11690-11695. |
| APA | Feng, Tao.,Su, Jia.,Ding, Zhi-Hui.,Zheng, Yong-Tang.,Li, Yan.,...&Liu, Ji-Kai.(2011).Chemical Constituents and Their Bioactivities of "Tongling White Ginger" (Zingiber officinale).JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,59(21),11690-11695. |
| MLA | Feng, Tao,et al."Chemical Constituents and Their Bioactivities of "Tongling White Ginger" (Zingiber officinale)".JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY 59.21(2011):11690-11695. |
入库方式： OAI收割
来源：上海药物研究所
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