A homogalacturonan from the radix of Platycodon grandiflorum and the anti-angiogenesis activity of poly-/oligogalacturonic acids derived therefrom
文献类型：期刊论文
| 作者 | Xu, Yuxia2; Dong, Qun2; Qiu, Hong2; Ma, Chung-Wah1; Ding, Kan2
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| 刊名 | CARBOHYDRATE RESEARCH
 |
| 出版日期 | 2011-09-27 |
| 卷号 | 346期号:13页码:1930-1936 |
| 关键词 | Anti-angiogenesis Homogalacturonan Platycodon grandiflorum Oligogalacturonic acid |
| ISSN号 | 0008-6215 |
| DOI | 10.1016/j.carres.2011.05.011 |
| 文献子类 | Article |
| 英文摘要 | A polysaccharide, PGA4-3b, with an average molecular weight of 8.9 kDa estimated by high-performance gel-permeation chromatography (HPGPC), was isolated from radix of Platycodon grandiflorum (Jacq.) A. DC. Using monosaccharide analysis, methylation analysis and NMR spectroscopy, PGA4-3b was elucidated to be a linear poly-(1 -> 4)-alpha-D-galactopyranosyluronic acid that contains no methyl ester groups. Partial acid hydrolysis of PGA4-3b yielded a series of poly-or oligogalacturonic acids with different degrees of polymerization (DP), that is, 4-3bde, 4-3bde-O-1, 4-3bde-O-2, 4-3bde-O-3, and 4-3bde-O-4. Cell tube formation inhibition tests with human microvascular endothelial cells (HMEC) for antiangiogenesis analysis showed that 4-3bde-O-1 and 4-3bde-O-2, the fractions with higher molecular weights, could inhibit tube formation, while the native PGA4-3b and low molecular weight fraction 4-3bde-O-3 and 4-3bde-O4 are ineffective. Moreover, 4-3bde-O-2 with DP 5-10 impaired cell tube formation in a dose-dependent way, suggesting its potential to be developed as an anti-angiogenesis drug. This is the first time oligogalacturonic acids are reported to show an anti-angiogenesis effect. (C) 2011 Elsevier Ltd. All rights reserved. |
| WOS关键词 | HERICIUM-ERINACEUS ; FRUITING BODIES ; GROWTH-FACTORS ; RESPONSES ; PECTINS ; OLIGOSACCHARIDES ; DEGRADATION ; INHIBITORS ; PATHWAYS ; SULFATE |
| 资助项目 | National Science Foundation of China[30870551] ; Key New Drug Creation and Manufacturing Program of China[2009ZX09501-011] ; Key New Drug Creation and Manufacturing Program of China[2009ZX09103-071] ; Key New Drug Creation and Manufacturing Program of China[2009ZX09301-001] |
| WOS研究方向 | Biochemistry & Molecular Biology ; Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000300551700036 |
| 出版者 | ELSEVIER SCI LTD |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/278397]  |
| 专题 | 药理学第三研究室 |
| 通讯作者 | Dong, Qun |
| 作者单位 | 1.Lee Kum Kee Hlth Prod Grp Ltd, Hong Kong, Hong Kong, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Mat Med, Glycobiol & Glycochem Lab, Shanghai 201203, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Xu, Yuxia,Dong, Qun,Qiu, Hong,et al. A homogalacturonan from the radix of Platycodon grandiflorum and the anti-angiogenesis activity of poly-/oligogalacturonic acids derived therefrom[J]. CARBOHYDRATE RESEARCH,2011,346(13):1930-1936. |
| APA | Xu, Yuxia,Dong, Qun,Qiu, Hong,Ma, Chung-Wah,&Ding, Kan.(2011).A homogalacturonan from the radix of Platycodon grandiflorum and the anti-angiogenesis activity of poly-/oligogalacturonic acids derived therefrom.CARBOHYDRATE RESEARCH,346(13),1930-1936. |
| MLA | Xu, Yuxia,et al."A homogalacturonan from the radix of Platycodon grandiflorum and the anti-angiogenesis activity of poly-/oligogalacturonic acids derived therefrom".CARBOHYDRATE RESEARCH 346.13(2011):1930-1936. |
入库方式： OAI收割
来源：上海药物研究所
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