Structure of a polysaccharide from Gastrodia elata Bl., and oligosaccharides prepared thereof with anti-pancreatic cancer cell growth activities
文献类型：期刊论文
| 作者 | Chen, Xia2; Cao, Dianxiu2; Zhou, Ling2; Jin, Hongying1; Dong, Qun2; Yao, Jian2; Ding, Kan2
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| 刊名 | CARBOHYDRATE POLYMERS
 |
| 出版日期 | 2011-08-30 |
| 卷号 | 86期号:3页码:1300-1305 |
| 关键词 | Gastrodia elata Bl. Poly-/oligosaccharide Anti-cancer Pancreatic cancer |
| ISSN号 | 0144-8617 |
| DOI | 10.1016/j.carbpol.2011.06.029 |
| 文献子类 | Article |
| 英文摘要 | To discover anti-pancreatic cancer cells growth inhibitor, a new water-soluble glucan, WTMA, was isolated from the rhizome of Gastrodia elate Bl. The mean molecular weight of the polysaccharide was estimated to be 7.0 x 10(5) Da by high performance gel permeation chromatography (HPGPC). The structure of WTMA was characterized by GC, GC-MS, NMR and MALDI-TOF. WTMA was deduced as an alpha-(1 --> 4)-glucan with alpha-(1 --> 4) linked branches attached to O-6 at branch points. Bioactivity tests in vitro indicated that WTMA and its partial acid hydrolysis-derived mixture product, WTMA-AD-O, could significantly inhibit the proliferation of pancreatic cancer cells. However, WTMA-DE, the degraded polysaccharide without branch chain by isoamylase, did not inhibit the proliferation of pancreatic cancer cells. Thus side chain on WTMA was deduced to be required for the anti-cancer cell activity. Further study demonstrated that WTMA and all of its hydrolysis products had no inhibition effect on liver LO2 cells. (C) 2011 Elsevier Ltd. All rights reserved. |
| WOS关键词 | GRIFOLA-FRONDOSA ; ANTITUMOR-ACTIVITY ; SODIUM-HYDROXIDE ; LENTINUS-EDODES ; 5-FLUOROURACIL ; CONFORMATION ; BODIES ; ALPHA |
| 资助项目 | Chinese Academy of Sciences, China[00000000] ; National Science & Technology Major Project "Key New Drug Creation and Manufacturing Program"[2009ZX09301-001] ; National Science & Technology Major Project "Key New Drug Creation and Manufacturing Program"[2009ZX09501-011] ; National Science & Technology Major Project "Key New Drug Creation and Manufacturing Program"[2009ZX09103-071] |
| WOS研究方向 | Chemistry ; Polymer Science |
| 语种 | 英语 |
| WOS记录号 | WOS:000295308500028 |
| 出版者 | ELSEVIER SCI LTD |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/278428]  |
| 专题 | 药理学第三研究室 |
| 通讯作者 | Ding, Kan |
| 作者单位 | 1.Shanghai Univ Tradit Chinese Med, Inst Chinese Mat Med, Shanghai 201203, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Mat Med, Glycochem & Glycobiol Lab, Shanghai 201203, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Chen, Xia,Cao, Dianxiu,Zhou, Ling,et al. Structure of a polysaccharide from Gastrodia elata Bl., and oligosaccharides prepared thereof with anti-pancreatic cancer cell growth activities[J]. CARBOHYDRATE POLYMERS,2011,86(3):1300-1305. |
| APA | Chen, Xia.,Cao, Dianxiu.,Zhou, Ling.,Jin, Hongying.,Dong, Qun.,...&Ding, Kan.(2011).Structure of a polysaccharide from Gastrodia elata Bl., and oligosaccharides prepared thereof with anti-pancreatic cancer cell growth activities.CARBOHYDRATE POLYMERS,86(3),1300-1305. |
| MLA | Chen, Xia,et al."Structure of a polysaccharide from Gastrodia elata Bl., and oligosaccharides prepared thereof with anti-pancreatic cancer cell growth activities".CARBOHYDRATE POLYMERS 86.3(2011):1300-1305. |
入库方式： OAI收割
来源：上海药物研究所
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