A Novel Water-Soluble Heptaplatin Analogue with Improved Antitumor Activity and Reduced Toxicity
文献类型：期刊论文
| 作者 | Liu, Weiping2; Chen, Xizhu2; Ye, Qingsong2; Xu, Yongping3; Xie, Chengying3 ; Xie, Mingjin1; Chang, Qiaowen2; Lou, Liguang3
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| 刊名 | INORGANIC CHEMISTRY
 |
| 出版日期 | 2011-06-20 |
| 卷号 | 50期号:12页码:5324-5326 |
| ISSN号 | 0020-1669 |
| DOI | 10.1021/ic200436u |
| 文献子类 | Article |
| 英文摘要 | A novel water-soluble heptaplatin analogue, cis-[(4R,5R)-4,5-bis-(aminomethyl)-2-isopropyl-1,3-dioxo-lane](3-hydroxy-1,1-cyclobutanedicarboxylato)platinum-(II), has been synthesized and biologically evaluated. The complex shows more activity and less toxicity than its parent drug heptaplatin, exhibiting the great potential for further development. |
| WOS关键词 | ANTICANCER PLATINUM COMPLEXES ; ADVANCED GASTRIC-CANCER ; DRUGS ; 5-FLUOROURACIL ; COMBINATION ; CISPLATIN ; DESIGN |
| 资助项目 | National New Drug Development Program of China[2009ZX 09103-109] ; Yunnan Science Foundation[2008CC020] |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000291422100006 |
| 出版者 | AMER CHEMICAL SOC |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/278498]  |
| 专题 | 药理学第一研究室 |
| 通讯作者 | Lou, Liguang |
| 作者单位 | 1.Yunnan Univ, Dept Chem, Kunming 650091, Peoples R China 2.Kunming Inst Precious Met, State Key Lab Adv Technol PGMs, Kunming 650106, Peoples R China; 3.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Liu, Weiping,Chen, Xizhu,Ye, Qingsong,et al. A Novel Water-Soluble Heptaplatin Analogue with Improved Antitumor Activity and Reduced Toxicity[J]. INORGANIC CHEMISTRY,2011,50(12):5324-5326. |
| APA | Liu, Weiping.,Chen, Xizhu.,Ye, Qingsong.,Xu, Yongping.,Xie, Chengying.,...&Lou, Liguang.(2011).A Novel Water-Soluble Heptaplatin Analogue with Improved Antitumor Activity and Reduced Toxicity.INORGANIC CHEMISTRY,50(12),5324-5326. |
| MLA | Liu, Weiping,et al."A Novel Water-Soluble Heptaplatin Analogue with Improved Antitumor Activity and Reduced Toxicity".INORGANIC CHEMISTRY 50.12(2011):5324-5326. |
入库方式： OAI收割
来源：上海药物研究所
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