Cell Biological Manifestations of Bisdioxopiperazines: Treatment of Human Tumor Cell Lines in Culture
文献类型：期刊论文
| 作者 | Lu, Da-Yong3; Lu, Ding-Ren1; Ding, Jian2
|
| 刊名 | ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY
 |
| 出版日期 | 2010-11 |
| 卷号 | 10期号:9页码:657-660 |
| ISSN号 | 1871-5206 |
| 关键词 | Bisdioxopiperazine compounds razoxane probimane MST-16 neoplasm metastasis cell movement GTPses actin mammary cancer MTX assay cell migration |
| DOI | 10.2174/187152010794479843 |
| 文献子类 | Article |
| 英文摘要 | British developed Bisdioxopiperazine compound (Biz compounds) {ICRF-159 or ICRF-187 (razoxane, Raz)} which was the first agent ever to be observed inhibiting and controlling the spontaneous pulmonary metastases of murine Lewis Lung Carcinoma (LLC) tumor model worldwide. Since 1980, two new Biz compounds {probimane (Pro, AT-2153, MST-2) and MST-16} have been synthesized at the Shanghai Institute of Materia Medica, Chinese Academy of Sciences, PR China, based on structural modifications from British developed Biz compounds. Despite some similarities and differences of structural and pharmacological activities observed between Raz, Pro and MST-16, the systematic comparisons of their pharmacological activities and mechanisms, especially on neoplasm metastases, are still much needed. This work demonstrates that Biz compounds may inhibit tumor cell migration in vitro through a Matrigel-Coated Transwell plate assay and a wound-healing assay by using three human mammary tumor cell lines (MDA-MB-231, MDA-MB-435 and MDA-MB-468). Pro, ICRF-187 and MST-16 affect the network of actin assembly. We conclude that Biz compounds might inhibit neoplasm metastases via affecting a cascade of GTPases, cell skeleton polarizations and cell movements. |
| WOS关键词 | ACTIN CYTOSKELETON ; CANCER METASTASIS ; RHO-GTPASES ; ANGIOGENESIS ; GROWTH ; -)-1,2-BIS(3,5-DIOXOPIPERAZIN-1-YL)PROPANE ; ACTIVATION ; MECHANISMS ; INHIBITOR ; MIGRATION |
| WOS研究方向 | Oncology ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| 出版者 | BENTHAM SCIENCE PUBL LTD |
| WOS记录号 | WOS:000288318800002 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/278727]  |
| 专题 | 药理学第一研究室 |
| 通讯作者 | Lu, Ding-Ren |
| 作者单位 | 1.Shanghai Univ, Coll Sci, Shanghai 200444, Peoples R China; 2.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China 3.Shanghai Univ, Sch Life Sci, Shanghai 200444, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Lu, Da-Yong,Lu, Ding-Ren,Ding, Jian. Cell Biological Manifestations of Bisdioxopiperazines: Treatment of Human Tumor Cell Lines in Culture[J]. ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY,2010,10(9):657-660. |
| APA | Lu, Da-Yong,Lu, Ding-Ren,&Ding, Jian.(2010).Cell Biological Manifestations of Bisdioxopiperazines: Treatment of Human Tumor Cell Lines in Culture.ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY,10(9),657-660. |
| MLA | Lu, Da-Yong,et al."Cell Biological Manifestations of Bisdioxopiperazines: Treatment of Human Tumor Cell Lines in Culture".ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY 10.9(2010):657-660. |
入库方式： OAI收割
来源：上海药物研究所
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