Synthesis and biological evaluation of cytotoxic activity of novel anthracene L-rhamnopyranosides
文献类型：期刊论文
| 作者 | Song, Gaopeng3; Liu, Hongchun1 ; Zhang, Wei2; Geng, Meiyu1; Li, Yingxia2
|
| 刊名 | BIOORGANIC & MEDICINAL CHEMISTRY
 |
| 出版日期 | 2010-07-15 |
| 卷号 | 18期号:14页码:5183-5193 |
| 关键词 | Anthracene L-rhamnopyranosides Derivatives Synthesis Cytotoxicity DNA binding |
| ISSN号 | 0968-0896 |
| DOI | 10.1016/j.bmc.2010.05.064 |
| 文献子类 | Article |
| 英文摘要 | A series of anthracene L-rhamnopyranosides were designed and synthesized in a practical way and their cytotoxic activity was examined in vitro. Most compounds exhibited both potent cytotoxicity against several tumor cell lines and high DNA binding capacity. The preliminary results showed that subtle modifications of rhamnosyl moiety in anthracene rhamnosides with acetyl group had a selective toxicity for different tumor cells and the displacement of C-10 carbonyl group in emodin by acetylmethylene group was helpful to improve the inhibitory activity. Lipophilicity of the anthracene glycosides was not a crucial factor for cytotoxicity and most molecules with good cytotoxicity could inhibit the catalytic activity of Top2 alpha. (C) 2010 Elsevier Ltd. All rights reserved. |
| WOS关键词 | DNA-BINDING ; BIS(SUBSTITUTED AMINOALKYLAMINO)ANTHRAQUINONES ; RHAMNUS-NEPALENSIS ; HL-60 CELLS ; APOPTOSIS ; EMODIN ; AGENTS ; ASSAYS |
| 资助项目 | national Natural Basic Research Program of China[2003CB716400] |
| WOS研究方向 | Biochemistry & Molecular Biology ; Pharmacology & Pharmacy ; Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000279744700036 |
| 出版者 | PERGAMON-ELSEVIER SCIENCE LTD |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/278831]  |
| 专题 | 药理学第一研究室 |
| 通讯作者 | Geng, Meiyu |
| 作者单位 | 1.Chinese Acad Sci, Div Antitumor Pharmacol, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China; 2.Fudan Univ, Sch Pharm, Shanghai 201203, Peoples R China; 3.S China Agr Univ, Coll Resources & Environm, Guangzhou 510642, Guangdong, Peoples R China |
| 推荐引用方式 GB/T 7714 | Song, Gaopeng,Liu, Hongchun,Zhang, Wei,et al. Synthesis and biological evaluation of cytotoxic activity of novel anthracene L-rhamnopyranosides[J]. BIOORGANIC & MEDICINAL CHEMISTRY,2010,18(14):5183-5193. |
| APA | Song, Gaopeng,Liu, Hongchun,Zhang, Wei,Geng, Meiyu,&Li, Yingxia.(2010).Synthesis and biological evaluation of cytotoxic activity of novel anthracene L-rhamnopyranosides.BIOORGANIC & MEDICINAL CHEMISTRY,18(14),5183-5193. |
| MLA | Song, Gaopeng,et al."Synthesis and biological evaluation of cytotoxic activity of novel anthracene L-rhamnopyranosides".BIOORGANIC & MEDICINAL CHEMISTRY 18.14(2010):5183-5193. |
入库方式： OAI收割
来源：上海药物研究所
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