Unusual Dimeric Chemical Structure for a Carboplatin Analogue as a Potential Anticancer Complex
文献类型：期刊论文
| 作者 | Xie, Mingjin2; Liu, Weiping3; Lou, Liguang1 ; Chen, Xizhu3; Ye, Qingsong3; Yu, Yao3; Chang, Qiaowen3; Hou, Shuqian3
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| 刊名 | INORGANIC CHEMISTRY
 |
| 出版日期 | 2010-07-05 |
| 卷号 | 49期号:13页码:5792-5794 |
| ISSN号 | 0020-1669 |
| DOI | 10.1021/ic100638u |
| 文献子类 | Article |
| 英文摘要 | An unexpected and unusual dimeric platinum(II) tetracarboxylate complex was obtained by the reaction of cis-[Pt(NH3)(2)I-2] with disilver dicarboxylate. The complex exhibits greater in vitro anticancer activity and lower toxicity in mice than its parent compound, carboplatin, and is therefore worthy of further evaluation as a potential antitumor dinuclear platinum agent. |
| WOS关键词 | PLATINUM(II) COMPLEXES ; X-RAY ; CRYSTAL-STRUCTURES ; AGENTS ; CISPLATIN ; DESIGN |
| 资助项目 | National Natural Science Foundation of China[20861004] ; National Key New Drug Contrive Project[2009ZX09103-109] ; Provincial Natural Science Foundation of Yunnan[2008CCO20] ; Provincial Natural Science Foundation of Yunnan[2009CD006] |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000279211500006 |
| 出版者 | AMER CHEMICAL SOC |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/278836]  |
| 专题 | 药理学第一研究室 |
| 通讯作者 | Liu, Weiping |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China 2.Yunnan Univ, Dept Chem, Kunming 650091, Peoples R China; 3.Kunming Inst Precious Met, State Key Lab Adv Technol PGMs, Kunming 650106, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Xie, Mingjin,Liu, Weiping,Lou, Liguang,et al. Unusual Dimeric Chemical Structure for a Carboplatin Analogue as a Potential Anticancer Complex[J]. INORGANIC CHEMISTRY,2010,49(13):5792-5794. |
| APA | Xie, Mingjin.,Liu, Weiping.,Lou, Liguang.,Chen, Xizhu.,Ye, Qingsong.,...&Hou, Shuqian.(2010).Unusual Dimeric Chemical Structure for a Carboplatin Analogue as a Potential Anticancer Complex.INORGANIC CHEMISTRY,49(13),5792-5794. |
| MLA | Xie, Mingjin,et al."Unusual Dimeric Chemical Structure for a Carboplatin Analogue as a Potential Anticancer Complex".INORGANIC CHEMISTRY 49.13(2010):5792-5794. |
入库方式： OAI收割
来源：上海药物研究所
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