Evaluation of water soluble beta-D-glucan from Auricularia auricular-judae as potential anti-tumor agent
文献类型：期刊论文
| 作者 | Ma, Zhaocheng1; Wang, Jianguo1; Zhang, Lina1; Zhang, Yufeng3; Ding, Kan2
|
| 刊名 | CARBOHYDRATE POLYMERS
 |
| 出版日期 | 2010-05-05 |
| 卷号 | 80期号:3页码:977-983 |
| 关键词 | Auricularia auricula-judae Polysaccharide Anti-tumor activity Apoptosis |
| ISSN号 | 0144-8617 |
| DOI | 10.1016/j.carbpol.2010.01.015 |
| 文献子类 | Article |
| 英文摘要 | A water soluble beta-D-glucan was isolated by 70% ethanol aqueous solution from Auricularia auricula-judae, coded as AAG. AAG exhibited strong inhibition against Acinar cell carcinoma (ACC) proliferation. The in vivo tests showed that AAG significantly inhibited tumor growth in a dose-dependent fashion, but not because of cytotoxicity. All the doses showed certain inhibition ratios against tumor-cell growth, while the dose of 20 mg/kg exhibited highest anti-tumor activities. Moreover, the enhancement ratios of body weight for all the doses were significantly higher than that for 5-fluorouracil (5-Fu). Fluorescence microscopy observed the apoptosis tumor cell induced by AGG sample. The results from TUNEL assay further confirmed the apoptosis in Sarcoma 180 solid tumor. Immunohistochemistry for apoptosis-related proteins Bax and Bcl-2 expression tests revealed that AAG induced S-180 tumor cell apoptosis by up-regulation of Bax and down-regulation of Bcl-2 expression. These findings demonstrated that the AAG has biological activities and could be considered as a candidate for possible anti-tumor drugs. (C) 2010 Elsevier Ltd. All rights reserved. |
| WOS关键词 | CELL-DEATH ; TREMELLA-FUCIFORMIS ; BCL-X ; APOPTOSIS ; BAX ; POLYSACCHARIDES ; CONFORMATION ; EXPRESSION ; CARCINOMA ; MYCELIA |
| 资助项目 | National Natural Science Foundation of China[30530850] ; High-Technology Research and Development Program of China[2006AA02z102] |
| WOS研究方向 | Chemistry ; Polymer Science |
| 语种 | 英语 |
| WOS记录号 | WOS:000276987800049 |
| 出版者 | ELSEVIER SCI LTD |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/278901]  |
| 专题 | 药理学第三研究室 |
| 通讯作者 | Zhang, Lina |
| 作者单位 | 1.Wuhan Univ, Dept Chem, Wuhan 430072, Peoples R China; 2.Chinese Acad Sci, Glycochem & Glycobiol Lab, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China 3.Wuhan Univ, Sch Stomatol, Wuhan 430079, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Ma, Zhaocheng,Wang, Jianguo,Zhang, Lina,et al. Evaluation of water soluble beta-D-glucan from Auricularia auricular-judae as potential anti-tumor agent[J]. CARBOHYDRATE POLYMERS,2010,80(3):977-983. |
| APA | Ma, Zhaocheng,Wang, Jianguo,Zhang, Lina,Zhang, Yufeng,&Ding, Kan.(2010).Evaluation of water soluble beta-D-glucan from Auricularia auricular-judae as potential anti-tumor agent.CARBOHYDRATE POLYMERS,80(3),977-983. |
| MLA | Ma, Zhaocheng,et al."Evaluation of water soluble beta-D-glucan from Auricularia auricular-judae as potential anti-tumor agent".CARBOHYDRATE POLYMERS 80.3(2010):977-983. |
入库方式： OAI收割
来源：上海药物研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。