A Novel Synthetic Analog of 5, 8-Disubstituted Quinazolines Blocks Mitosis and Induces Apoptosis of Tumor Cells by Inhibiting Microtubule Polymerization
文献类型：期刊论文
| 作者 | Tian, Wei2; Qin, Lili2; Song, Qiaoling1; He, Li1; Ai, Midan1; Jin, Yi1 ; Zhou, Zuyu1; You, Song2; Long, Yaqiu1; Yu, Qiang1
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| 刊名 | PLOS ONE
 |
| 出版日期 | 2010-05-05 |
| 卷号 | 5期号:5 |
| ISSN号 | 1932-6203 |
| DOI | 10.1371/journal.pone.0010499 |
| 文献子类 | Article |
| 英文摘要 | Many mitosis inhibitors are powerful anticancer drugs. Tremendous efforts have been made to identify new anti-mitosis compounds for developing more effective and less toxic anti-cancer drugs. We have identified LJK-11, a synthetic analog of 5, 8-disubstituted quinazolines, as a novel mitotic blocker. LJK-11 inhibited growth and induced apoptosis of many different types of tumor cells. It prevented mitotic spindle formation and arrested cells at early phase of mitosis. Detailed in vitro analysis demonstrated that LJK-11 inhibited microtubule polymerization. In addition, LJK-11 had synergistic effect with another microtubule inhibitor colchicine on blocking mitosis, but not with vinblastine or nocodazole. Therefore, LJK-11 represents a novel anti-microtubule structure. Understanding the function and mechanism of LJK-11 will help us to better understand the action of anti-microtubule agents and to design better anti-cancer drugs. |
| WOS关键词 | BREAST-CANCER CELLS ; IN-VITRO ; ANTIMITOTIC ACTIVITY ; DESTABILIZING DRUGS ; CENTROMERE DYNAMICS ; SPINDLE CHECKPOINT ; AGENTS ; TAXOL ; TUBULIN ; BINDING |
| 资助项目 | China National Natural Science Foundation[30672481] ; China National Natural Science Foundation[30771097] ; Shanghai Science and Technology[03XD14002] |
| WOS研究方向 | Science & Technology - Other Topics |
| 语种 | 英语 |
| WOS记录号 | WOS:000277379400032 |
| 出版者 | PUBLIC LIBRARY SCIENCE |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/278902]  |
| 专题 | 药理学第一研究室 药物安全性评价中心 |
| 通讯作者 | Tian, Wei |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 200031, Peoples R China 2.Shenyang Pharmaceut Univ, Sch Life Sci & Biopharmaceut, Shenyang, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Tian, Wei,Qin, Lili,Song, Qiaoling,et al. A Novel Synthetic Analog of 5, 8-Disubstituted Quinazolines Blocks Mitosis and Induces Apoptosis of Tumor Cells by Inhibiting Microtubule Polymerization[J]. PLOS ONE,2010,5(5). |
| APA | Tian, Wei.,Qin, Lili.,Song, Qiaoling.,He, Li.,Ai, Midan.,...&Yu, Qiang.(2010).A Novel Synthetic Analog of 5, 8-Disubstituted Quinazolines Blocks Mitosis and Induces Apoptosis of Tumor Cells by Inhibiting Microtubule Polymerization.PLOS ONE,5(5). |
| MLA | Tian, Wei,et al."A Novel Synthetic Analog of 5, 8-Disubstituted Quinazolines Blocks Mitosis and Induces Apoptosis of Tumor Cells by Inhibiting Microtubule Polymerization".PLOS ONE 5.5(2010). |
入库方式： OAI收割
来源：上海药物研究所
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