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Vibralactones D-F from Cultures of the Basidiomycete Boreostereum vibrans

文献类型：期刊论文

作者Jiang, Meng-Yuan1,3; Zhang, Ling1,3; Dong, Ze-Jun1; Yang, Zhu-Liang1; Leng, Ying2; Liu, Ji-Kai1
刊名CHEMICAL & PHARMACEUTICAL BULLETIN
出版日期2010-01
卷号58期号:1页码:113-116
ISSN号0009-2363
关键词vibralactone 11 beta-hydroxysteroid dehydrogenase activity Boreostereum vibrans
DOI10.1248/cpb.58.113
文献子类Article
英文摘要Three new metabolites, vibralactones D-F (1-3) were isolated from cultures of the basidiomycete Boreostereum vibrans. The relative configuration of I was established on the basis of X-ray diffraction analysis, while the absolute configurations of 1-3 were assigned using a modified Mosher's method. Compound I showed weak inhibitory activities against isozymes of 11 beta-hydroxysteroid dehydrogenases (HSD) with IC50 values of 85.7 mu M (human HSD1), 295.2 mu M (mouse HSD1), and 87.1 mu M (human HSD2).
资助项目National Basic Research Program of China[2009CB522300] ; National Natural Sciences Foundation of China[30830113] ; Chinese Academy of Sciences[KSCX1-YW-R-24] ; Chinese Academy of Sciences[KSCX2-YW-G-025]
WOS研究方向Pharmacology & Pharmacy ; Chemistry
语种英语
出版者PHARMACEUTICAL SOC JAPAN
WOS记录号WOS:000273168400022
源URL[http://119.78.100.183/handle/2S10ELR8/279008]  
专题药理学第一研究室
通讯作者Liu, Ji-Kai
作者单位1.Chinese Acad Sci, State Key Lab Phytochem & Plant Resources W China, Kunming Inst Bot, Kunming 650204, Peoples R China;
2.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China
3.Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China;
推荐引用方式
GB/T 7714		 Jiang, Meng-Yuan,Zhang, Ling,Dong, Ze-Jun,et al. Vibralactones D-F from Cultures of the Basidiomycete Boreostereum vibrans[J]. CHEMICAL & PHARMACEUTICAL BULLETIN,2010,58(1):113-116.
APA Jiang, Meng-Yuan,Zhang, Ling,Dong, Ze-Jun,Yang, Zhu-Liang,Leng, Ying,&Liu, Ji-Kai.(2010).Vibralactones D-F from Cultures of the Basidiomycete Boreostereum vibrans.CHEMICAL & PHARMACEUTICAL BULLETIN,58(1),113-116.
MLA Jiang, Meng-Yuan,et al."Vibralactones D-F from Cultures of the Basidiomycete Boreostereum vibrans".CHEMICAL & PHARMACEUTICAL BULLETIN 58.1(2010):113-116.

入库方式： OAI收割

来源：上海药物研究所

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