Waltonitone induces human hepatocellular carcinoma cells apoptosis in vitro and in vivo
文献类型：期刊论文
| 作者 | Zhang, Zhang1,2; Wang, Shuo1; Qiu, Hong1; Duan, Chaohui2; Ding, Kan1 ; Wang, Zhengtao2
|
| 刊名 | CANCER LETTERS
 |
| 出版日期 | 2009-12-28 |
| 卷号 | 286期号:2页码:223-231 |
| 关键词 | Gentiana waltonii Burkill Waltonitone Hepatocellular carcinoma Apoptosis Caspase |
| ISSN号 | 0304-3835 |
| DOI | 10.1016/j.canlet.2009.05.023 |
| 文献子类 | Article |
| 英文摘要 | Waltonitone, a new ursane-type pentacyclic triterpene isolated from Gentian waltonii Burkill significantly inhibited human hepatocellular carcinoma BEL-7402 cells growth. Apoptosis induced by waltonitone was characterized by AO/EB staining and flow cytometric analysis. Apoptosis microarray assay results showed BCL-2 family genes might especially play an important role in waltonitone-induced apoptosis. RT-PCR and Western blotting analysis showed that waltonitone could induce tumor cell apoptosis via both death receptor and mitochondria pathways. Meanwhile, the inhibitory effect of waltonitone was examined in vivo using BEL-7402 tumor cells xenografted into athymic mice model. In summary, these studies demonstrated that waltonitone might inhibit hepatocellular carcinoma cells growth and induce apoptosis in vitro and in vivo. (C) 2009 Elsevier Ireland Ltd. All rights reserved. |
| WOS关键词 | TRADITIONAL CHINESE MEDICINE ; RECEPTOR-MEDIATED APOPTOSIS ; URSOLIC ACID ; ACTIVATION ; DEATH ; MITOCHONDRIA ; LIVER ; MACROPHAGES ; PATHWAYS |
| 资助项目 | High Tech Research and Development (863) Program[2006AAM102] ; National Natural Science Foundation of China (NSFC)[30770484] |
| WOS研究方向 | Oncology |
| 语种 | 英语 |
| WOS记录号 | WOS:000272576400010 |
| 出版者 | ELSEVIER IRELAND LTD |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/279060]  |
| 专题 | 药理学第三研究室 |
| 通讯作者 | Ding, Kan |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, Glycobiol & Glycochem Lab, Shanghai 201203, Peoples R China; 2.Shanghai Univ Tradit Chinese Med, Key Lab Standardizat Chinese Med, Minist Educ, Inst Chinese Mat Med, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, Zhang,Wang, Shuo,Qiu, Hong,et al. Waltonitone induces human hepatocellular carcinoma cells apoptosis in vitro and in vivo[J]. CANCER LETTERS,2009,286(2):223-231. |
| APA | Zhang, Zhang,Wang, Shuo,Qiu, Hong,Duan, Chaohui,Ding, Kan,&Wang, Zhengtao.(2009).Waltonitone induces human hepatocellular carcinoma cells apoptosis in vitro and in vivo.CANCER LETTERS,286(2),223-231. |
| MLA | Zhang, Zhang,et al."Waltonitone induces human hepatocellular carcinoma cells apoptosis in vitro and in vivo".CANCER LETTERS 286.2(2009):223-231. |
入库方式： OAI收割
来源：上海药物研究所
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