中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
Effects of Magnesium Lithospermate B and its Analogues on Ca2+ Homeostasis in Cultured Rat Thoracic Aorta Vascular Smooth Muscle Cells

文献类型:期刊论文

作者Chen, Li1,2; Xuan, Li-Jiang1; Wang, Yi-Ping1
刊名PLANTA MEDICA
出版日期2009-12
卷号75期号:15页码:1573-1579
关键词magnesium lithospermate B sodium rosmarinate magnesium lithospermate vascular smooth muscle cells Fluo-3
ISSN号0032-0943
DOI10.1055/s-0029-1185905
文献子类Article
英文摘要Magnesium lithospermate B (MLB), sodium rosmarinate (SR), and magnesium lithospermate (ML) are biologically active components isolated from aqueous extracts of the Chinese medicine Danshen, the dried root and rhizome of Salvia miltiorrhiza Bunge (Labiatae). These compounds share similar chemical structures of polyphenols and oligomer condensates with caffeic acid. In this study, we compared the effects of MLB, ML, and SR on intracellular Ca2+ concentrations ([Ca2+](i)) in cultured rat thoracic aorta vascular smooth muscle cells (VSMCs), using the Ca2+-sensitive dye, Fluo-3, as an indicator. In our experiments, MLB, ML, and SR did not affect the basal value of [Ca2+](i) in VSMCs. In the absence of extracellular Ca2+, the [Ca2+](i) increase in VSMCs induced by 20 mu M ATP was attenuated by MLB, ML, and SR in a dose-dependent manner. Moreover, under this condition, MLB suppressed the increase in [Ca2+](i) in VSMCs induced by 1 mu M thapsigargin, but not ML or SR. In the presence of extracellular Ca2+, the [Ca2+](i) increase in VSMCs induced by 60 mM KCl was attenuated by MLB and SR in a close-dependent manner, but not by ML. These results suggest that MLB, ML and SR regulate Ca2+ homeostasis in VSMCs via different pathways. Our findings should aid in elucidating the mechanisms of the vasodilator action of aqueous extracts of Salvia miltiorrhiza.
WOS关键词SALVIANOLIC-ACID-B ; ROSMARINIC ACID ; NITRIC-OXIDE ; PC12 CELLS ; MILTIORRHIZA ; CALCIUM ; INHIBITION ; ANTIOXIDANT ; MECHANISM ; COMPONENT
资助项目National Basic Research Program of China[2009CB930300]
WOS研究方向Plant Sciences ; Pharmacology & Pharmacy ; Integrative & Complementary Medicine
语种英语
WOS记录号WOS:000273178400004
出版者GEORG THIEME VERLAG KG
源URL[http://119.78.100.183/handle/2S10ELR8/279079]  
专题药理学第一研究室
通讯作者Wang, Yi-Ping
作者单位1.Chinese Acad Sci, State Key Lab New Drug Res, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China;
2.Chinese Acad Sci, Grad Sch, Beijing, Peoples R China
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Chen, Li,Xuan, Li-Jiang,Wang, Yi-Ping. Effects of Magnesium Lithospermate B and its Analogues on Ca2+ Homeostasis in Cultured Rat Thoracic Aorta Vascular Smooth Muscle Cells[J]. PLANTA MEDICA,2009,75(15):1573-1579.
APA Chen, Li,Xuan, Li-Jiang,&Wang, Yi-Ping.(2009).Effects of Magnesium Lithospermate B and its Analogues on Ca2+ Homeostasis in Cultured Rat Thoracic Aorta Vascular Smooth Muscle Cells.PLANTA MEDICA,75(15),1573-1579.
MLA Chen, Li,et al."Effects of Magnesium Lithospermate B and its Analogues on Ca2+ Homeostasis in Cultured Rat Thoracic Aorta Vascular Smooth Muscle Cells".PLANTA MEDICA 75.15(2009):1573-1579.

入库方式: OAI收割

来源:上海药物研究所

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