Effects of Magnesium Lithospermate B and its Analogues on Ca2+ Homeostasis in Cultured Rat Thoracic Aorta Vascular Smooth Muscle Cells
文献类型：期刊论文
| 作者 | Chen, Li1,2; Xuan, Li-Jiang1 ; Wang, Yi-Ping1
|
| 刊名 | PLANTA MEDICA
 |
| 出版日期 | 2009-12 |
| 卷号 | 75期号:15页码:1573-1579 |
| 关键词 | magnesium lithospermate B sodium rosmarinate magnesium lithospermate vascular smooth muscle cells Fluo-3 |
| ISSN号 | 0032-0943 |
| DOI | 10.1055/s-0029-1185905 |
| 文献子类 | Article |
| 英文摘要 | Magnesium lithospermate B (MLB), sodium rosmarinate (SR), and magnesium lithospermate (ML) are biologically active components isolated from aqueous extracts of the Chinese medicine Danshen, the dried root and rhizome of Salvia miltiorrhiza Bunge (Labiatae). These compounds share similar chemical structures of polyphenols and oligomer condensates with caffeic acid. In this study, we compared the effects of MLB, ML, and SR on intracellular Ca2+ concentrations ([Ca2+](i)) in cultured rat thoracic aorta vascular smooth muscle cells (VSMCs), using the Ca2+-sensitive dye, Fluo-3, as an indicator. In our experiments, MLB, ML, and SR did not affect the basal value of [Ca2+](i) in VSMCs. In the absence of extracellular Ca2+, the [Ca2+](i) increase in VSMCs induced by 20 mu M ATP was attenuated by MLB, ML, and SR in a dose-dependent manner. Moreover, under this condition, MLB suppressed the increase in [Ca2+](i) in VSMCs induced by 1 mu M thapsigargin, but not ML or SR. In the presence of extracellular Ca2+, the [Ca2+](i) increase in VSMCs induced by 60 mM KCl was attenuated by MLB and SR in a close-dependent manner, but not by ML. These results suggest that MLB, ML and SR regulate Ca2+ homeostasis in VSMCs via different pathways. Our findings should aid in elucidating the mechanisms of the vasodilator action of aqueous extracts of Salvia miltiorrhiza. |
| WOS关键词 | SALVIANOLIC-ACID-B ; ROSMARINIC ACID ; NITRIC-OXIDE ; PC12 CELLS ; MILTIORRHIZA ; CALCIUM ; INHIBITION ; ANTIOXIDANT ; MECHANISM ; COMPONENT |
| 资助项目 | National Basic Research Program of China[2009CB930300] |
| WOS研究方向 | Plant Sciences ; Pharmacology & Pharmacy ; Integrative & Complementary Medicine |
| 语种 | 英语 |
| WOS记录号 | WOS:000273178400004 |
| 出版者 | GEORG THIEME VERLAG KG |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/279079]  |
| 专题 | 药理学第一研究室 |
| 通讯作者 | Wang, Yi-Ping |
| 作者单位 | 1.Chinese Acad Sci, State Key Lab New Drug Res, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China; 2.Chinese Acad Sci, Grad Sch, Beijing, Peoples R China |
| 推荐引用方式 GB/T 7714 | Chen, Li,Xuan, Li-Jiang,Wang, Yi-Ping. Effects of Magnesium Lithospermate B and its Analogues on Ca2+ Homeostasis in Cultured Rat Thoracic Aorta Vascular Smooth Muscle Cells[J]. PLANTA MEDICA,2009,75(15):1573-1579. |
| APA | Chen, Li,Xuan, Li-Jiang,&Wang, Yi-Ping.(2009).Effects of Magnesium Lithospermate B and its Analogues on Ca2+ Homeostasis in Cultured Rat Thoracic Aorta Vascular Smooth Muscle Cells.PLANTA MEDICA,75(15),1573-1579. |
| MLA | Chen, Li,et al."Effects of Magnesium Lithospermate B and its Analogues on Ca2+ Homeostasis in Cultured Rat Thoracic Aorta Vascular Smooth Muscle Cells".PLANTA MEDICA 75.15(2009):1573-1579. |
入库方式： OAI收割
来源：上海药物研究所
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