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Berberine Inhibits Hepatic Stellate Cell Proliferation and Prevents Experimental Liver Fibrosis

文献类型：期刊论文

作者Sun, Xu2; Zhang, Xiaodong2; Hu, Hui2; Lu, Yina2; Chen, Jie2; Yasuda, Kazuki1; Wang, Heyao2
刊名BIOLOGICAL & PHARMACEUTICAL BULLETIN
出版日期2009-09
卷号32期号:9页码:1533-1537
关键词liver fibrosis hepatic stellate cell berberine cell cycle cell proliferation
ISSN号0918-6158
DOI10.1248/bpb.32.1533
文献子类Article
英文摘要Proliferation of hepatic stellate cells (HSCs) is central for the development of fibrosis during liver injury. Our aim in this study was to determine whether berberine could inhibit HSC proliferation in vitro and prevent experimental liver fibrosis in vivo. Activated rat hepatic stellate cells (CFSCs) were incubated with various concentrations (0-20 mu g/ml) of berberine. After 48 h incubation, berberine significantly inhibited CFSC proliferation and induced cell cycle arrest in G1 phase. Real-time and Western blotting revealed that both p21 and p27 expression was markedly reduced by berberine. Berberine also decreased Akt phosphorylation and FoxO1 phosphorylation, which led to FoxO1 nuclear translocation. Berberine effectively prevented CCl4-induced liver fibrosis in mice, which was accompanied by a decrease in the number of activated HSCs. Thus, berberine was able to prevent liver fibrosis by inhibition of hepatic stellate cell proliferation.
WOS关键词TRANSCRIPTION FACTOR FOXO1 ; PROTEIN-KINASE ; CYCLE ARREST ; MECHANISM ; APOPTOSIS ; EXPRESSION ; P27(KIP1) ; PRODUCT ; RAT
资助项目National High Technology Research and Development Program of China (863 Program)[2007AA02Z301] ; Chinese Academy of Sciences[07G603L056]
WOS研究方向Pharmacology & Pharmacy
语种英语
WOS记录号WOS:000269349000009
出版者PHARMACEUTICAL SOC JAPAN
源URL[http://119.78.100.183/handle/2S10ELR8/279142]  
专题药理学第三研究室
通讯作者Wang, Heyao
作者单位1.Int Med Ctr Japan, Res Inst, Dept Metab Disorder, Tokyo 1628655, Japan
2.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China;
推荐引用方式
GB/T 7714		 Sun, Xu,Zhang, Xiaodong,Hu, Hui,et al. Berberine Inhibits Hepatic Stellate Cell Proliferation and Prevents Experimental Liver Fibrosis[J]. BIOLOGICAL & PHARMACEUTICAL BULLETIN,2009,32(9):1533-1537.
APA Sun, Xu.,Zhang, Xiaodong.,Hu, Hui.,Lu, Yina.,Chen, Jie.,...&Wang, Heyao.(2009).Berberine Inhibits Hepatic Stellate Cell Proliferation and Prevents Experimental Liver Fibrosis.BIOLOGICAL & PHARMACEUTICAL BULLETIN,32(9),1533-1537.
MLA Sun, Xu,et al."Berberine Inhibits Hepatic Stellate Cell Proliferation and Prevents Experimental Liver Fibrosis".BIOLOGICAL & PHARMACEUTICAL BULLETIN 32.9(2009):1533-1537.

入库方式： OAI收割

来源：上海药物研究所

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