7-Cycloalkylcamptothecin derivatives: Preparation and biological evaluation
文献类型：期刊论文
| 作者 | Li, Mingzong2; Jin, Wei1; Jiang, Chen3; Zheng, Chao2; Tang, Weidong1; You, Tianpa2; Lou, Liguang1
|
| 刊名 | BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
 |
| 出版日期 | 2009-08-01 |
| 卷号 | 19期号:15页码:4107-4109 |
| 关键词 | Camptothecin 7-Cycloalkylcamptothecin derivatives Anti-tumor Synthesis |
| ISSN号 | 0960-894X |
| DOI | 10.1016/j.bmcl.2009.06.010 |
| 文献子类 | Article |
| 英文摘要 | A series of 7-cycloalkylcamptothecin derivatives were synthesized from camptothecin with two methods. Their biological activities in vitro were evaluated with sulforhodamine-B (SRB) method on four types of human tumor cell lines A549/ATCC, HT29, NCI-H460 and HL60. Most of these camptothecin analogues show higher antitumor activity than the reference compounds SN-38 and Topotecan, with the IC50 values low to nM level. Structure-activity relationship studies of these compounds mostly match the conclusion we achieved before from quantitative structure-activity relationship (QSAR) research. (C) 2009 Elsevier Ltd. All rights reserved. |
| WOS关键词 | DNA-TOPOISOMERASE-I ; ANTITUMOR-ACTIVITY ; CAMPTOTHECIN ANALOGS ; CLEAVABLE COMPLEX ; STABILITY |
| WOS研究方向 | Pharmacology & Pharmacy ; Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000267900900023 |
| 出版者 | PERGAMON-ELSEVIER SCIENCE LTD |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/279169]  |
| 专题 | 药理学第一研究室 |
| 通讯作者 | You, Tianpa |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China; 2.Univ Sci & Technol China, Dept Chem, Hefei 230026, Anhui, Peoples R China; 3.China Pharmaceut Univ, Dept Basic Sci, Nanjing 210000, Jiangsu, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li, Mingzong,Jin, Wei,Jiang, Chen,et al. 7-Cycloalkylcamptothecin derivatives: Preparation and biological evaluation[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2009,19(15):4107-4109. |
| APA | Li, Mingzong.,Jin, Wei.,Jiang, Chen.,Zheng, Chao.,Tang, Weidong.,...&Lou, Liguang.(2009).7-Cycloalkylcamptothecin derivatives: Preparation and biological evaluation.BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,19(15),4107-4109. |
| MLA | Li, Mingzong,et al."7-Cycloalkylcamptothecin derivatives: Preparation and biological evaluation".BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 19.15(2009):4107-4109. |
入库方式： OAI收割
来源：上海药物研究所
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