Pentanol derivatives from basidiomycete Catathelasma imperiale and their 11 beta-hydroxysteroid dehydrogenases inhibitory activity
文献类型：期刊论文
| 作者 | Zhang, Ling2,3; Shen, Yu1; Zhu, Hua-Jie2; Wang, Fei2,4; Leng, Ying1 ; Liu, Ji-Kai2
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| 刊名 | JOURNAL OF ANTIBIOTICS
 |
| 出版日期 | 2009-05 |
| 卷号 | 62期号:5页码:239-242 |
| 关键词 | basidiomycete catathelasmols A-E Catathelasma imperiale pentanol derivatives 11 beta-hydroxysteroid dehydrogenases |
| ISSN号 | 0021-8820 |
| DOI | 10.1038/ja.2009.17 |
| 文献子类 | Article |
| 英文摘要 | Five new secondary metabolites derived from pentanol, namely catathelasmols A-E (1-5), were isolated from the fruiting bodies of the basidiomycete Catathelasma imperiale. Their structures were elucidated on the basis of spectroscopic analysis, and the absolute configurations were determined by computational chemistry. Compounds 3, 4 and 5 showed inhibitory activities against two isozymes of 11 beta-hydroxysteroid clehydrogenases (11 beta-HSD1 and 11 beta-HSD2), with IC50 values of 28.7-62.3 mu g ml(-1) (human 11 beta-HSD1), 30.4-149.2 mu g ml(-1) (mouse 11 beta-HSD1), 5.1-177 mu g ml(-1) (human 11 beta-HSD2) and 32.3-129 mu g ml(-1) (mouse 11 beta-HSD2), which catalyze the interconversion of cortisol and cortisone. The Journal of Antibiotics (2009) 62, 239-242; doi:10.1038/ja.2009.17; published online 27 March 2009 |
| WOS关键词 | ABSOLUTE-CONFIGURATIONS ; OPTICAL ROTATIONS ; TYPE-1 |
| 资助项目 | National Basic Research Program of China[2009CB522300] ; National Natural Science Foundation of China[30830113] ; Chinese Academy of Sciences[KSCX1-YW-R-24] ; Chinese Academy of Sciences[KSCY2-YW-G-025] |
| WOS研究方向 | Biotechnology & Applied Microbiology ; Immunology ; Microbiology ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000266798700002 |
| 出版者 | JAPAN ANTIBIOTICS RESEARCH ASSOC |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/279253]  |
| 专题 | 药理学第一研究室 |
| 通讯作者 | Liu, Ji-Kai |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 200031, Peoples R China; 2.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Peoples R China; 3.Chinese Acad Sci, Grad Univ, Beijing, Peoples R China; 4.BioBioPha Co Ltd, Kunming, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, Ling,Shen, Yu,Zhu, Hua-Jie,et al. Pentanol derivatives from basidiomycete Catathelasma imperiale and their 11 beta-hydroxysteroid dehydrogenases inhibitory activity[J]. JOURNAL OF ANTIBIOTICS,2009,62(5):239-242. |
| APA | Zhang, Ling,Shen, Yu,Zhu, Hua-Jie,Wang, Fei,Leng, Ying,&Liu, Ji-Kai.(2009).Pentanol derivatives from basidiomycete Catathelasma imperiale and their 11 beta-hydroxysteroid dehydrogenases inhibitory activity.JOURNAL OF ANTIBIOTICS,62(5),239-242. |
| MLA | Zhang, Ling,et al."Pentanol derivatives from basidiomycete Catathelasma imperiale and their 11 beta-hydroxysteroid dehydrogenases inhibitory activity".JOURNAL OF ANTIBIOTICS 62.5(2009):239-242. |
入库方式： OAI收割
来源：上海药物研究所
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