Sesquiterpenes from Cultures of the Basidiomycete Clitocybe conglobata and Their 11 beta-Hydroxysteroid Dehydrogenase Inhibitory Activity
文献类型：期刊论文
| 作者 | Xu, Di2,3; Sheng, Yu1; Zhou, Zhong-Yu2; Liu, Rong2; Leng, Ying1 ; Liu, Ji-Kai2
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| 刊名 | CHEMICAL & PHARMACEUTICAL BULLETIN
 |
| 出版日期 | 2009-04 |
| 卷号 | 57期号:4页码:433-435 |
| 关键词 | drimane sesquiterpene Clitocybe conglobata basidiomycete 11 beta-hydroxysteroid dehydrogenase |
| ISSN号 | 0009-2363 |
| DOI | 10.1248/cpb.57.433 |
| 文献子类 | Article |
| 英文摘要 | A new drimane sesquiterpenoid, 3-keto-drimenol (1), were isolated from cultures of the basidiomycete Clitocybe conglobata together with 3 beta-hydroxy-11-acetyldrimene (2), 3 beta-hydroxydrimenol (3), 11,12-dihydroxydrimene (4), 3 beta-hydroxy-11,12-O-isopropyidrimene (5), and 3 beta,11,12-trihydroxydrimene (6). Their structures were established from MS and NMR experiments. Compounds 1, 3, and 6 showed inhibitory activities against two isozymes of 11 beta-hydroxysteroid dehydrogenases with IC50 1.7-8.0 mu g/ml (human 11 beta-HSD1), 10.7-24.1 mu g/ml (mouse 11 beta-HSD1); 177.0-220.0 mu g/ml (human 11 beta-HSD2),250.5-500.2 mu g/ml (mouse 11 beta-HSD2), respectively, which catalyze the interconversion of active cortisol and inactive cortisone. |
| WOS关键词 | METABOLITES ; TYPE-1 |
| 资助项目 | National Basic Research Program of China[2009CB522300] ; National Natural Sciences Foundation of China[30830113] ; Chinese Academy of Sciences[KSCX1-YW-R-24] ; Chinese Academy of Sciences[KSCX2-YW-G-025] |
| WOS研究方向 | Pharmacology & Pharmacy ; Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000264616800021 |
| 出版者 | PHARMACEUTICAL SOC JAPAN |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/279273]  |
| 专题 | 药理学第一研究室 |
| 通讯作者 | Leng, Ying |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China; 2.Chinese Acad Sci, State Key Lab Phytochem & Plant Resources W China, Kunming Inst Bot, Kunming 650204, Peoples R China; 3.S China Agr Univ, Dept Entomol, Guangzhou 510642, Guangdong, Peoples R China |
| 推荐引用方式 GB/T 7714 | Xu, Di,Sheng, Yu,Zhou, Zhong-Yu,et al. Sesquiterpenes from Cultures of the Basidiomycete Clitocybe conglobata and Their 11 beta-Hydroxysteroid Dehydrogenase Inhibitory Activity[J]. CHEMICAL & PHARMACEUTICAL BULLETIN,2009,57(4):433-435. |
| APA | Xu, Di,Sheng, Yu,Zhou, Zhong-Yu,Liu, Rong,Leng, Ying,&Liu, Ji-Kai.(2009).Sesquiterpenes from Cultures of the Basidiomycete Clitocybe conglobata and Their 11 beta-Hydroxysteroid Dehydrogenase Inhibitory Activity.CHEMICAL & PHARMACEUTICAL BULLETIN,57(4),433-435. |
| MLA | Xu, Di,et al."Sesquiterpenes from Cultures of the Basidiomycete Clitocybe conglobata and Their 11 beta-Hydroxysteroid Dehydrogenase Inhibitory Activity".CHEMICAL & PHARMACEUTICAL BULLETIN 57.4(2009):433-435. |
入库方式： OAI收割
来源：上海药物研究所
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