Effects of Pro-Arg, a Novel Dipeptide Derived from Protamine Hydrolysate on H2O2-Induced Oxidative Stress in Human Diploid Fibroblasts
文献类型：期刊论文
| 作者 | Wang, Yonggang1,2; Zhu, Fengrong2; Chen, Jie1; Han, Fusen2; Wang, Heyao1
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| 刊名 | BIOLOGICAL & PHARMACEUTICAL BULLETIN
 |
| 出版日期 | 2009-03 |
| 卷号 | 32期号:3页码:389-393 |
| 关键词 | antioxidant dipeptide human diploid fibroblast reactive oxygen species |
| ISSN号 | 0918-6158 |
| DOI | 10.1248/bpb.32.389 |
| 文献子类 | Article |
| 英文摘要 | Oxidative stress plays an important role in tissue damage associated with many different chronic degenerative diseases, such as cancer and cardiovascular disorders. In our previous study, it novel dipeptide Pro-Arg derived from protamine hydrolysates was found to possess significant antioxidative activity in vitro. In this study, we compared the antioxidant capabilities of purified and synthesized dipeptide (Pro-Arg) and found both of them had very strong hydroxyl-radical scavenging activity in vitro, even at a very low concentration. The protective effect of the dipeptide against oxidative stress was evaluated using H2O2-induced oxidative stress of human diploid fibroblasts MRC-5 cell model. Our results showed the dipeptide attenuated H2O2-induced cellular oxidative damage, and normalized S phase arrest of MRC-5 cells exposed to H2O2, Our findings demonstrate that Pro-Arg can protect against oxidative stress/damage and H2O2-induced human diploid fibroblasts cell death. |
| WOS关键词 | L-ARGININE ; ANTIOXIDATIVE PEPTIDES ; SOYBEAN PROTEIN ; BEEF PATTIES ; AMINO-ACIDS ; IN-VITRO ; CARNOSINE ; INHIBITION ; PURIFICATION ; RESVERATROL |
| 资助项目 | National Supporting Project of the Eleventh Five-Year Plan[2006BAD27B06] ; National High Technology Research and Development Program of China[2007AA02Z301] |
| WOS研究方向 | Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000263777800014 |
| 出版者 | PHARMACEUTICAL SOC JAPAN |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/279298]  |
| 专题 | 药理学第三研究室 |
| 通讯作者 | Wang, Heyao |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China; 2.Global R&D Ctr Tianjin Tiens Grp, Tianjin 301700, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Yonggang,Zhu, Fengrong,Chen, Jie,et al. Effects of Pro-Arg, a Novel Dipeptide Derived from Protamine Hydrolysate on H2O2-Induced Oxidative Stress in Human Diploid Fibroblasts[J]. BIOLOGICAL & PHARMACEUTICAL BULLETIN,2009,32(3):389-393. |
| APA | Wang, Yonggang,Zhu, Fengrong,Chen, Jie,Han, Fusen,&Wang, Heyao.(2009).Effects of Pro-Arg, a Novel Dipeptide Derived from Protamine Hydrolysate on H2O2-Induced Oxidative Stress in Human Diploid Fibroblasts.BIOLOGICAL & PHARMACEUTICAL BULLETIN,32(3),389-393. |
| MLA | Wang, Yonggang,et al."Effects of Pro-Arg, a Novel Dipeptide Derived from Protamine Hydrolysate on H2O2-Induced Oxidative Stress in Human Diploid Fibroblasts".BIOLOGICAL & PHARMACEUTICAL BULLETIN 32.3(2009):389-393. |
入库方式： OAI收割
来源：上海药物研究所
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