New oligosaccharides prepared by acid hydrolysis of the polysaccharides from Nerium indicum Mill and their anti-angiogenesis activities
文献类型：期刊论文
| 作者 | Hu, Ke1,2; Liu, Qin1; Wang, Shunchun2; Ding, Kan1
|
| 刊名 | CARBOHYDRATE RESEARCH
 |
| 出版日期 | 2009-01-26 |
| 卷号 | 344期号:2页码:198-203 |
| 关键词 | Nerium indicum Galactooligosaccharide Anti-angiogenesis activity |
| ISSN号 | 0008-6215 |
| DOI | 10.1016/j.carres.2008.10.019 |
| 文献子类 | Article |
| 英文摘要 | To discover drug candidates with anti-angiogenesis activity for cancer therapeutics, three galactooligosaccharides (OJ1-OJ3) were prepared by acid hydrolysis of the polysaccharides from Nerium indicum Mill. Their structures were characterized using sugar analysis, methylation analysis, and both 1D and 2D NMR spectroscopy, complemented by mass spectrometry. They were hexasaccharide (0J1), a pentasaccharide (OJ2), and an undecasaccharide (OJ3), which was a new linear galactan. Bioactivity testing in vitro showed that OJ2 and OJ3 significantly inhibited the HMEC-1 (human microvascular endothelial cell) cell tube formation. (C) 2008 Elsevier Ltd. All rights reserved. |
| WOS关键词 | MECHANISMS ; CELLS |
| 资助项目 | National Natural Science Foundation of China (NSFC)[30670470] ; National Natural Science Foundation of China (NSFC)[30770484] ; High Tech Research and Development (863) Program[2006AA02Z102] ; Knowledge Innovation Program of the Chinese Academy of Sciences[KSCX1 -YW-R-1 8] ; The New Drug Discovery Research Program of the Shanghai Institute of Materia Medica, Chinese Academy of Sciences[07G604F036] |
| WOS研究方向 | Biochemistry & Molecular Biology ; Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000262798700006 |
| 出版者 | ELSEVIER SCI LTD |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/279339]  |
| 专题 | 药理学第三研究室 |
| 通讯作者 | Wang, Shunchun |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China 2.Shanghai Univ Tradit Chinese Med, Inst Chinese Mat Med, Shanghai 201203, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Hu, Ke,Liu, Qin,Wang, Shunchun,et al. New oligosaccharides prepared by acid hydrolysis of the polysaccharides from Nerium indicum Mill and their anti-angiogenesis activities[J]. CARBOHYDRATE RESEARCH,2009,344(2):198-203. |
| APA | Hu, Ke,Liu, Qin,Wang, Shunchun,&Ding, Kan.(2009).New oligosaccharides prepared by acid hydrolysis of the polysaccharides from Nerium indicum Mill and their anti-angiogenesis activities.CARBOHYDRATE RESEARCH,344(2),198-203. |
| MLA | Hu, Ke,et al."New oligosaccharides prepared by acid hydrolysis of the polysaccharides from Nerium indicum Mill and their anti-angiogenesis activities".CARBOHYDRATE RESEARCH 344.2(2009):198-203. |
入库方式： OAI收割
来源：上海药物研究所
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