Inhibitory Effect of 2,4,2 ',4 '-Tetrahydroxy-3-(3-methyl-2-butenyl)-chalcone on Tyrosinase Activity and Melanin Biosynthesis
文献类型：期刊论文
| 作者 | Zhang, Xiaodong2; Hu, Xiao1; Hou, Aijun1; Wang, Heyao2
|
| 刊名 | BIOLOGICAL & PHARMACEUTICAL BULLETIN
 |
| 出版日期 | 2009-01 |
| 卷号 | 32期号:1页码:86-90 |
| 关键词 | 2,4,2',4'-tetrahydroxy-3-(3-methyl-2-butenyl)-chalcone tyrosinase melanin melanin biosynthesis |
| ISSN号 | 0918-6158 |
| DOI | 10.1248/bpb.32.86 |
| 文献子类 | Article |
| 英文摘要 | 2,4,2',4'-Tetrahydroxy-3-(3-methyl,1-2-butenyl)-chalcone (TMBC), a naturally occurring compound from Morus nigra, modulated melanogenesis by inhibiting tyrosinase. TMBC inhibited the L-dopa oxidase activity of mushroom tyrosinase with an IC50 value of 0.95 +/- 0.04 mu m, which was more potent than kojic acid (IC50 = 24.88 +/- 1.13 mu M), a well-known tyrosinase inhibitor. The kinetic studies of tyrosinase inhibition revealed that TMBC acts as a competitive inhibitor of mushroom tyrosinase with L-dopa as the substrate. Furthermore, TMBC effectively inhibited both cellular tyrosinase activity and melanin biosynthesis in B16 melanoma cells without significant cytotoxicity. The inhibitor), effect of TMBC on melanogenesis was attributed to the direct inhibition of tyrosinase activity, rather than the suppression of tyrosinase gene expression. These results indicated that TMBC may be a new promising pigmentation-altering agent for cosmetic or therapeutic applications. |
| WOS关键词 | KOJIC ACID ; MUSHROOM TYROSINASE ; HUMAN MELANOCYTES ; PIGMENTATION ; MELANOGENESIS ; HYDROQUINONE ; AGENTS ; SKIN |
| 资助项目 | National High Technology Research[00000000] ; Development Program of China[2007AA02Z301] ; New Drug Basic Research Program of the Shanghai Institute of Materia Medica, Chinese Academy of Sciences[07G603L056] |
| WOS研究方向 | Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000262069200015 |
| 出版者 | PHARMACEUTICAL SOC JAPAN |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/279349]  |
| 专题 | 药理学第三研究室 |
| 通讯作者 | Hou, Aijun |
| 作者单位 | 1.Fudan Univ, Sch Pharm, Dept Pharmacol, Shanghai 200032, Peoples R China; 2.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, Xiaodong,Hu, Xiao,Hou, Aijun,et al. Inhibitory Effect of 2,4,2 ',4 '-Tetrahydroxy-3-(3-methyl-2-butenyl)-chalcone on Tyrosinase Activity and Melanin Biosynthesis[J]. BIOLOGICAL & PHARMACEUTICAL BULLETIN,2009,32(1):86-90. |
| APA | Zhang, Xiaodong,Hu, Xiao,Hou, Aijun,&Wang, Heyao.(2009).Inhibitory Effect of 2,4,2 ',4 '-Tetrahydroxy-3-(3-methyl-2-butenyl)-chalcone on Tyrosinase Activity and Melanin Biosynthesis.BIOLOGICAL & PHARMACEUTICAL BULLETIN,32(1),86-90. |
| MLA | Zhang, Xiaodong,et al."Inhibitory Effect of 2,4,2 ',4 '-Tetrahydroxy-3-(3-methyl-2-butenyl)-chalcone on Tyrosinase Activity and Melanin Biosynthesis".BIOLOGICAL & PHARMACEUTICAL BULLETIN 32.1(2009):86-90. |
入库方式： OAI收割
来源：上海药物研究所
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