Structure and chain conformation of a (1 -> 6)-alpha-D-glucan from the root of Pueraria lobata (Willd.) Ohwi and the antioxidant activity of its sulfated derivative
文献类型：期刊论文
| 作者 | Cui, Hengxiang1,2; Liu, Qin1; Tao, Yongzhen3; Zhang, Hongfeng2; Zhang, Lina3; Ding, Kan1
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| 刊名 | CARBOHYDRATE POLYMERS
 |
| 出版日期 | 2008-11-21 |
| 卷号 | 74期号:4页码:771-778 |
| 关键词 | Pueraria lobata (1 -> 6)-alpha-D-glucan chain conformation antioxidant effect sulfated polysaccharide |
| ISSN号 | 0144-8617 |
| DOI | 10.1016/j.carbpol.2008.04.034 |
| 文献子类 | Article |
| 英文摘要 | A water soluble glucan, PLB-2C, was isolated from the water extract of the root of Pueraria lobota (Willd) Ohwi using anion-exchange and gel permeation chromatography. Its structure was investigated by gas chromatography (GC) gas chromatography-mass spectrometry (GC-MS), infrared (IR) spectra, and nuclear magnetic resonance (NMR) spectroscopy of heteronuclear single quantum coherence (HSQC) and heteronuclear multiple bond correlation (HMBC) techniques. The results indicated that PLB-2C was a linear glucan composed of (1 -> 6)-alpha-D-Glcp. Chain conformation study showed that the polysaccharide took random coil compact conformation. In vitro cell viability assay by MTT method, its sulfated derivative PLB-2CS which was substituted at 2-0, 3-0, 4-0 positions, at 0.1, 1, and 5 mg/ml, could attenuate PC12 cell damage significantly caused by hydrogen peroxide. (C) 2008 Elsevier Ltd. All rights reserved. |
| WOS关键词 | MAGNETIC-RESONANCE SPECTROSCOPY ; MAJOR ISOFLAVONOID CONTENTS ; HEPARAN-SULFATE ; IN-VITRO ; POLYSACCHARIDES ; GLUCAN ; PROTEOGLYCANS ; METHYLATION ; ACTIVATION ; MIRIFICA |
| 资助项目 | National Natural Science Foundation of China (NSFC)[30670470] ; High Tech Research and Development (863) Program[2006AA02Z102] ; Shanghai Institute of Materia Medica[00000000] ; Chinese Academy of Sciences[07G604F036] |
| WOS研究方向 | Chemistry ; Polymer Science |
| 语种 | 英语 |
| WOS记录号 | WOS:000259765300003 |
| 出版者 | ELSEVIER SCI LTD |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/279428]  |
| 专题 | 药理学第三研究室 |
| 通讯作者 | Ding, Kan |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, Glycochem & Glycobiol Lab, Shanghai 201203, Peoples R China; 2.E China Normal Univ, Sch Life Sci, Shanghai 200062, Peoples R China; 3.Wuhan Univ, Dept Chem, Wuhan 430072, Peoples R China |
| 推荐引用方式 GB/T 7714 | Cui, Hengxiang,Liu, Qin,Tao, Yongzhen,et al. Structure and chain conformation of a (1 -> 6)-alpha-D-glucan from the root of Pueraria lobata (Willd.) Ohwi and the antioxidant activity of its sulfated derivative[J]. CARBOHYDRATE POLYMERS,2008,74(4):771-778. |
| APA | Cui, Hengxiang,Liu, Qin,Tao, Yongzhen,Zhang, Hongfeng,Zhang, Lina,&Ding, Kan.(2008).Structure and chain conformation of a (1 -> 6)-alpha-D-glucan from the root of Pueraria lobata (Willd.) Ohwi and the antioxidant activity of its sulfated derivative.CARBOHYDRATE POLYMERS,74(4),771-778. |
| MLA | Cui, Hengxiang,et al."Structure and chain conformation of a (1 -> 6)-alpha-D-glucan from the root of Pueraria lobata (Willd.) Ohwi and the antioxidant activity of its sulfated derivative".CARBOHYDRATE POLYMERS 74.4(2008):771-778. |
入库方式： OAI收割
来源：上海药物研究所
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