Structural elucidation and immune-enhancing activity of an arabinogalactan from flowers of Carthamus tinctorius L.
文献类型：期刊论文
| 作者 | Yao, Yanli1,2; Yao, Jian1,2; Du, Zhenyun1,2; Wang, Peipei1,2 ; Ding, Kan1,2
|
| 刊名 | CARBOHYDRATE POLYMERS
 |
| 出版日期 | 2018-12-15 |
| 卷号 | 202页码:134-142 |
| 关键词 | Carthamus tinctorius L. Arabinogalactan Structure Immunity |
| ISSN号 | 0144-8617 |
| DOI | 10.1016/j.carbpol.2018.08.098 |
| 文献子类 | Article |
| 英文摘要 | Previous studies showed that polysaccharides from flowers of Carthamus tinctorius L. had immunomodulating activities. However, their structures were little known. Here, an arabinogalactan, named as HH1-1 with a relative molecular weight of 70.9 kDa, was isolated from flowers of Carthamus tinctorius L. by hot water extraction, followed by purification of a DEAE-Cellulose 32 column and a Sephacryl S-200HR column, subsequently. The structure of HH1-1 was evaluated to have a backbone of 1,6-linked Galp branched at C-3 by side chain of 1,3-linked Galp, with sub-branches attached at its C-3 position. The branches mainly contained 1,5-linked, 1,3,5 linked, terminal arabinose and terminal galactose. Biological activity assays showed that this polysaccharide had immune-enhancing activity by multiple ways, including promoting immune responses by activation of NF-kappa B signaling and increasing TNF-alpha, IL-1 beta and iNOS expressions in lymphocytes and macrophages. |
| WOS关键词 | NF-KAPPA-B ; ACID PHENETHYL ESTER ; SIGNALING PATHWAYS ; CELLS ; POLYSACCHARIDES ; ACTIVATION ; EXTRACT ; LYMPHOCYTES ; MACROPHAGES ; INHIBITOR |
| 资助项目 | Program of Shanghai Subject Chief Scientist[16XD1404500] ; National Natural Science Foundation of China (NSFC)[31670814] ; Shanghai Science and Technology Development Funds[14YF1407800] |
| WOS研究方向 | Chemistry ; Polymer Science |
| 语种 | 英语 |
| WOS记录号 | WOS:000446027100017 |
| 出版者 | ELSEVIER SCI LTD |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/279468]  |
| 专题 | 药理学第三研究室 国家新药筛选中心 |
| 通讯作者 | Wang, Peipei; Ding, Kan |
| 作者单位 | 1.Univ Chinese Acad Sci, 19A,Yuquan Rd, Beijing 100049, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Materia Med, Glycochem & Glycobiol Lab, Key Lab Receptor Res, Shanghai 201203, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Yao, Yanli,Yao, Jian,Du, Zhenyun,et al. Structural elucidation and immune-enhancing activity of an arabinogalactan from flowers of Carthamus tinctorius L.[J]. CARBOHYDRATE POLYMERS,2018,202:134-142. |
| APA | Yao, Yanli,Yao, Jian,Du, Zhenyun,Wang, Peipei,&Ding, Kan.(2018).Structural elucidation and immune-enhancing activity of an arabinogalactan from flowers of Carthamus tinctorius L..CARBOHYDRATE POLYMERS,202,134-142. |
| MLA | Yao, Yanli,et al."Structural elucidation and immune-enhancing activity of an arabinogalactan from flowers of Carthamus tinctorius L.".CARBOHYDRATE POLYMERS 202(2018):134-142. |
入库方式： OAI收割
来源：上海药物研究所
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