Structural characterization and anti-A549 lung cancer cells bioactivity of a polysaccharide from Houttuynia cordata
文献类型：期刊论文
| 作者 | Han, Kun1,2,3; Jin, Can1,3; Chen, Huanjun1,3; Wang, Peipei1,3 ; Yu, Mei2; Ding, Kan1,3
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| 刊名 | INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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| 出版日期 | 2018-12 |
| 卷号 | 120页码:288-296 |
| 关键词 | Houttuynia cordata Pectin Anti-cancer |
| ISSN号 | 0141-8130 |
| DOI | 10.1016/j.ijbiomac.2018.08.061 |
| 文献子类 | Article |
| 英文摘要 | A water-soluble pectic polysaccharide HCA4S1 was isolated from Houttuynia cordata and purified by DEAE Cellulose and Sephacryl S-300 column. HCA4S1 with an average molecular weight of 21.7 kDa mainly consisted of rhamnose, galacturonic acid, galactose, and arabinose. By using partial acid hydrolysis, methylation analysis, and NMR spectra, the structure of this polysaccharide is found to have a backbone consisting of 1,4-linked alpha D GalA and 1,2,4-linked alpha L Rha. The latter was substituted at C-4 position by 1,4 linked, 1,6-linked beta Gall), or Teminal linked beta Gal. Bioactivity test showed that this polysaccharide might inhibit the proliferation of A549 lung cancer cell by inducing cell cycle arrest and apoptosis. The expression of cleaved caspase 3 and cyclinBl was observed to be upregulated after the treatment with this polysaccharide. Collectively, these results suggest that the pectin HCA4S1 from Houttuynia cordata is of potential value in the treatment of lung cancer, though the underlying mechanisms remain to be further confirmed. (C) 2018 Published by Elsevier B.V. |
| WOS关键词 | SIGNALING PATHWAY ; EXTRACT ; APOPTOSIS ; INHIBITION ; STATISTICS ; ACID |
| 资助项目 | New Drug Creation and Manufacturing Program, Ministry of Science and Technology, the People Republic of China[2017ZX09305-003] ; State Key Program of National Natural Science Foundation of China[31230022] ; Program of Shanghai Subject Chief Scientist[16XD1404500] |
| WOS研究方向 | Biochemistry & Molecular Biology ; Chemistry ; Polymer Science |
| 语种 | 英语 |
| WOS记录号 | WOS:000452587500034 |
| 出版者 | ELSEVIER SCIENCE BV |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/279476]  |
| 专题 | 药理学第三研究室 |
| 通讯作者 | Yu, Mei; Ding, Kan |
| 作者单位 | 1.Univ Chinese Acad Sci, 19A Yuquan Rd, Beijing 100049, Peoples R China; 2.Huazhong Agr Univ, Coll Anim Sci & Technol, Minist Educ, Key Lab Agr Anim Genet Breeding & Reprod, Wuhan 430070, Hubei, Peoples R China 3.Chinese Acad Sci, Shanghai Inst Mat Med, Glycochem & Glycobiol Lab, Key Lab Receptor Res, 555 Zu Chong Zhi Rd, Shanghai 201203, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Han, Kun,Jin, Can,Chen, Huanjun,et al. Structural characterization and anti-A549 lung cancer cells bioactivity of a polysaccharide from Houttuynia cordata[J]. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,2018,120:288-296. |
| APA | Han, Kun,Jin, Can,Chen, Huanjun,Wang, Peipei,Yu, Mei,&Ding, Kan.(2018).Structural characterization and anti-A549 lung cancer cells bioactivity of a polysaccharide from Houttuynia cordata.INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,120,288-296. |
| MLA | Han, Kun,et al."Structural characterization and anti-A549 lung cancer cells bioactivity of a polysaccharide from Houttuynia cordata".INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES 120(2018):288-296. |
入库方式： OAI收割
来源：上海药物研究所
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