A pectin from fruits of Lycium barbarum L. decreases Beta-amyloid peptide production through modulating APP processing
文献类型：期刊论文
| 作者 | Zhou, Lishuang1,2,3; Liao, Wenfeng1,3; Zeng, Hui1,3; Yao, Yanli1,3; Chen, Xia1,3; Ding, Kan1,2,3
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| 刊名 | CARBOHYDRATE POLYMERS
 |
| 出版日期 | 2018-12-01 |
| 卷号 | 201页码:65-74 |
| 关键词 | Lycium barbarum L. Pectin A beta(42) Alzheimer's disease Amyloid precursor protein processing |
| ISSN号 | 0144-8617 |
| DOI | 10.1016/j.carbpol.2018.08.050 |
| 文献子类 | Article |
| 英文摘要 | Here, a pectin LBP1C-2 with the molecular weight of 99.8 kDa was purified from fruits of Lycium barbarum L. Its structure was elucidated as a backbone of alternate 1, 2-linked alpha-Rhap and 1, 4-linked alpha-GalpA, with branches of terminal (T)-, 1, 3-, 1, 6- and 1, 3, 6-linked beta-Galp, T-, 1, 5- and 1, 3, 5-linked alpha-Araf and T-linked beta-Rhap substituted at C-4 of 1, 2, 4-linked alpha-Rhap. The cell-based experiments indicated that LBP1C-2 suppressed A beta(42) production in a dose-dependent manner with no cytotoxicity. Further study showed that expression of beta-site APP cleaving enzyme 1 (BACE1) was attenuated by LBP1C-2, while expression of ADAM10 was up-regulated by LBP1C-2. Moreover, LBP1C-2 promoted the expression of insulin-degradation enzyme (IDE). These results suggested that LBP1C-2 might be a leading compound for anti-Alzheimer's disease therapy by decreasing A beta(4)(2) production through mediating BACE1 and ADAM10 as well as IDE expression. |
| WOS关键词 | ALZHEIMERS-DISEASE ; PROTEIN ; POLYSACCHARIDES ; MECHANISMS ; HETEROPOLYSACCHARIDE ; AGGREGATION ; A-BETA(42) ; MODEL ; MICE |
| 资助项目 | Key Basic Study on Function and Bioactivity of Lycium barbarum L. - Ningxia and Chinese Academy of Sciences[00000000] ; National Natural Science Foundation of China[31500651] ; National Natural Science Foundation of China[31230022] ; New Drug Creation and Manufacturing Program, Ministry of Science and Technology, People Republic of China[2017ZX09305-003] ; Program of Shanghai Subject Chief Scientist[16XD1404500] |
| WOS研究方向 | Chemistry ; Polymer Science |
| 语种 | 英语 |
| WOS记录号 | WOS:000445030100008 |
| 出版者 | ELSEVIER SCI LTD |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/279488]  |
| 专题 | 药理学第三研究室 |
| 通讯作者 | Ding, Kan |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, Key Lab Receptor Res, Glycochem & Glycobiol Lab, 555 Zu Chong Zhi Rd, Shanghai 201203, Peoples R China; 2.Zunyi Med Univ, Sch Pharm, 201 Dalian Rd, Zunyi 563000, Peoples R China 3.Univ Chinese Acad Sci, 19A Yuquan Rd, Beijing 100049, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Zhou, Lishuang,Liao, Wenfeng,Zeng, Hui,et al. A pectin from fruits of Lycium barbarum L. decreases Beta-amyloid peptide production through modulating APP processing[J]. CARBOHYDRATE POLYMERS,2018,201:65-74. |
| APA | Zhou, Lishuang,Liao, Wenfeng,Zeng, Hui,Yao, Yanli,Chen, Xia,&Ding, Kan.(2018).A pectin from fruits of Lycium barbarum L. decreases Beta-amyloid peptide production through modulating APP processing.CARBOHYDRATE POLYMERS,201,65-74. |
| MLA | Zhou, Lishuang,et al."A pectin from fruits of Lycium barbarum L. decreases Beta-amyloid peptide production through modulating APP processing".CARBOHYDRATE POLYMERS 201(2018):65-74. |
入库方式： OAI收割
来源：上海药物研究所
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