Non-coordination planer cis-and trans-configuration of cis-[Pt(II)(mixed-NH3/RNH2)(3-OH-cyclobutane-1,1-dicarboxylate)]: separation, characterization, and anticancer activity
文献类型：期刊论文
| 作者 | Jiang, Jing3; Qiu, Jie1; Lou, Liguang2 ; Gao, Anli3; Hou, Shuqian3; Liu, Weiping3
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| 刊名 | RESEARCH ON CHEMICAL INTERMEDIATES
 |
| 出版日期 | 2018-11 |
| 卷号 | 44期号:11页码:6479-6487 |
| 关键词 | Platinum(II) complexes Anticancer activity 3-OH-cyclobutane-1 1-dicarboxylate Mixed-NH3/RNH2 Non-coordination planer cis- trans-isomerism |
| ISSN号 | 0922-6168 |
| DOI | 10.1007/s11164-018-3503-0 |
| 文献子类 | Article |
| 英文摘要 | Two isomers of cis-[Pt(II)(mixed-NH3/RNH2)(3-OH-cyclobutane-1,1-dicarboxylate)] (R=cycopentyl, cyclohexyl) were separated, structurally characterized and tested for their anticancer activity. X-ray structural analysis revealed that this isomerism originates from two opposite spatial orientations of the hydroxyl group on the cyclobutane ring in relation to the coordinated NH3, resulting in cis- and trans-configurations. The two isomers have approximately equal anticancer activity, probably due to a relatively long distance between the hydroxyl group and the Pt(II) coordination plane. Therefore, the separation of such isomers is not recommended during drug development. |
| WOS关键词 | CANCER-CHEMOTHERAPY ; PLATINUM COMPLEXES ; ANTITUMOR-ACTIVITY ; AGENTS ; DRUGS ; DELIVERY ; HISTORY ; FUTURE ; ANALOG |
| 资助项目 | Natural Science Foundation of China[21661018] ; Yunnan Provincial R&D Project of China[2014BC010] ; Yunnan Provincial R&D Project of China[2017ZF010] |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000449307900003 |
| 出版者 | SPRINGER |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/279513]  |
| 专题 | 药理学第一研究室 |
| 通讯作者 | Liu, Weiping |
| 作者单位 | 1.Lincan Maternal & Child Hlth Care Hosp, Kaiyuan, Yunnan, Peoples R China; 2.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai, Peoples R China 3.Kunming Inst Precious Met, State Key Lab Platinum Grp Met, Kunming, Yunnan, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Jiang, Jing,Qiu, Jie,Lou, Liguang,et al. Non-coordination planer cis-and trans-configuration of cis-[Pt(II)(mixed-NH3/RNH2)(3-OH-cyclobutane-1,1-dicarboxylate)]: separation, characterization, and anticancer activity[J]. RESEARCH ON CHEMICAL INTERMEDIATES,2018,44(11):6479-6487. |
| APA | Jiang, Jing,Qiu, Jie,Lou, Liguang,Gao, Anli,Hou, Shuqian,&Liu, Weiping.(2018).Non-coordination planer cis-and trans-configuration of cis-[Pt(II)(mixed-NH3/RNH2)(3-OH-cyclobutane-1,1-dicarboxylate)]: separation, characterization, and anticancer activity.RESEARCH ON CHEMICAL INTERMEDIATES,44(11),6479-6487. |
| MLA | Jiang, Jing,et al."Non-coordination planer cis-and trans-configuration of cis-[Pt(II)(mixed-NH3/RNH2)(3-OH-cyclobutane-1,1-dicarboxylate)]: separation, characterization, and anticancer activity".RESEARCH ON CHEMICAL INTERMEDIATES 44.11(2018):6479-6487. |
入库方式： OAI收割
来源：上海药物研究所
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