Design, Syntheses and Anticancer Activities of Platinum(IV) Prodrugs with Dihydrogen Phosphate as an Axial Ligand
文献类型：期刊论文
| 作者 | Gao An-Li1; Xiong Qing-Feng1; Jiang Jing1; Yu Juan1; Lou Li-Guang2 ; Liu Wei-Ping1
|
| 刊名 | CHINESE JOURNAL OF INORGANIC CHEMISTRY
 |
| 出版日期 | 2018-09-10 |
| 卷号 | 34期号:9页码:1649-1654 |
| 关键词 | platinum(IV) complexes synthesis characterization anticancer activity |
| ISSN号 | 1001-4861 |
| DOI | 10.11862/CJIC.2018.211 |
| 文献子类 | Article |
| 英文摘要 | CPL-1501 and CPL-1504, two platinum(IV) prodrugs with dihydrogen phosphate as one axial ligand, were synthesized from cisplatin and oxaliplatin, respectively, as the starting material, and characterized by elemental analysis, IR as well as C-13 and P-31 NMR. Their reduction potential was measured via the cyclic voltammetry. The standard MTT was used to evaluate anticancer activity of the two prodrugs against several human cancer cell lines. CPL-1501 has a good water-solubility (10 mg.mL(-1)) and water-stability. With the favorable E-p values, it can be readily reduced to an active prototype cisplatin in the oxygen-deprived micro-environment of cancer cells. The biological tests reveal that CPL-1501 is able to inhibit the growth of cancer cells and its anticancer activity is comparable to that of cisplatin but much greater than that of carboplatin, whereas CPL-1504 does not show significant activity, probably due to its lower E-p values. |
| WOS关键词 | COMPLEXES ; DELIVERY ; THERAPY ; AGENTS ; DRUGS ; HEPTAPLATIN ; CISPLATIN ; REDUCTION |
| WOS研究方向 | Chemistry |
| 语种 | 中文 |
| CSCD记录号 | CSCD:6323811 |
| WOS记录号 | WOS:000446645600008 |
| 出版者 | CHINESE CHEMICAL SOC |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/279581]  |
| 专题 | 药理学第一研究室 |
| 通讯作者 | Jiang Jing; Liu Wei-Ping |
| 作者单位 | 1.Kunming Inst Precious Met, Platinum Based Drug Lab, Kunming 650106, Yunnan, Peoples R China; 2.Chinese Acad Sci, Shanghai Inst Mat Med, Tumor Pharmacol Lab, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Gao An-Li,Xiong Qing-Feng,Jiang Jing,et al. Design, Syntheses and Anticancer Activities of Platinum(IV) Prodrugs with Dihydrogen Phosphate as an Axial Ligand[J]. CHINESE JOURNAL OF INORGANIC CHEMISTRY,2018,34(9):1649-1654. |
| APA | Gao An-Li,Xiong Qing-Feng,Jiang Jing,Yu Juan,Lou Li-Guang,&Liu Wei-Ping.(2018).Design, Syntheses and Anticancer Activities of Platinum(IV) Prodrugs with Dihydrogen Phosphate as an Axial Ligand.CHINESE JOURNAL OF INORGANIC CHEMISTRY,34(9),1649-1654. |
| MLA | Gao An-Li,et al."Design, Syntheses and Anticancer Activities of Platinum(IV) Prodrugs with Dihydrogen Phosphate as an Axial Ligand".CHINESE JOURNAL OF INORGANIC CHEMISTRY 34.9(2018):1649-1654. |
入库方式： OAI收割
来源：上海药物研究所
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