Caffeic acid inhibits HCV replication via induction of IFN alpha antiviral response through p62-mediated Keap1/Nrf2 signaling pathway
文献类型：期刊论文
| 作者 | Shen, Jian1,3; Wang, Guifeng1 ; Zuo, Jianping1,2,3
|
| 刊名 | ANTIVIRAL RESEARCH
 |
| 出版日期 | 2018-06 |
| 卷号 | 154页码:166-173 |
| 关键词 | Caffeic acid Keap1 Nrf2 HO-1 |
| ISSN号 | 0166-3542 |
| DOI | 10.1016/j.antiviral.2018.04.008 |
| 文献子类 | Article |
| 英文摘要 | Hepatitis C virus (HCV) infection and its related liver disease have constituted a heavy burden worldwide. It had been reported that Drinking coffee could decrease mortality risk of HCV infected patients. Caffeic Acid (CA), the Coffee-related organic acid could inhibit HCV replication, however, the detailed mechanism of CA against HCV is unclear. In this study, we showed that CA could notably inhibit HCV replication. Mechanism study demonstrated that CA could induce HO-1 expression, which would trigger the IFNa antiviral response, and the antiviral effect of CA was attenuated when HO-1 activity was inhibited by SnPP (an HO-1 inhibitor). CA could also increase erythroid 2-related factor 2 (Nrf2) expression. When Nrf2 was knocked down by specific siRNA, HO-1 expression was concomitantly decreased while HCV expression was restored. Further study indicated that kelch-like ECH-associated protein 1 (keap1) expression was decreased by CA through p62/Sequestosome1 (p62)mediated autophagy, which would lead to the stabilization and accumulation of Nrf2. The decrease of keap1 was restored when p62 was silenced by specific p62 siRNA and when autophagy was inhibited, suggesting p62-mediated autophagy was required for CA-mediated keap1 downregulation. Taken together, the results demonstrated that CA could modulate Keap1/Nrf2 interaction via increasing p62 expression, leading to stabilization of Nrf2 and HO-1 induction, and elicit IFN alpha antiviral response to suppress HCV replication. |
| WOS关键词 | HEPATITIS-C VIRUS ; TRANSCRIPTION FACTOR NRF2 ; ANTIOXIDANT RESPONSE ; OXIDATIVE STRESS ; IN-VITRO ; SELECTIVE AUTOPHAGY ; HEME OXYGENASE-1 ; CELL LINE ; B-VIRUS ; EXPRESSION |
| 资助项目 | National Basic Research Program of China (973 Program)[2013CB911104] |
| WOS研究方向 | Pharmacology & Pharmacy ; Virology |
| 语种 | 英语 |
| WOS记录号 | WOS:000433651300020 |
| 出版者 | ELSEVIER SCIENCE BV |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/279734]  |
| 专题 | 药理学第一研究室 |
| 通讯作者 | Wang, Guifeng; Zuo, Jianping |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, Lab Immunopharmacol, Shanghai, Peoples R China; 2.Shanghai Univ Tradit Chinese Med, Lab Immunol & Virol, Shanghai, Peoples R China 3.Univ Chinese Acad Sci, Beijing, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Shen, Jian,Wang, Guifeng,Zuo, Jianping. Caffeic acid inhibits HCV replication via induction of IFN alpha antiviral response through p62-mediated Keap1/Nrf2 signaling pathway[J]. ANTIVIRAL RESEARCH,2018,154:166-173. |
| APA | Shen, Jian,Wang, Guifeng,&Zuo, Jianping.(2018).Caffeic acid inhibits HCV replication via induction of IFN alpha antiviral response through p62-mediated Keap1/Nrf2 signaling pathway.ANTIVIRAL RESEARCH,154,166-173. |
| MLA | Shen, Jian,et al."Caffeic acid inhibits HCV replication via induction of IFN alpha antiviral response through p62-mediated Keap1/Nrf2 signaling pathway".ANTIVIRAL RESEARCH 154(2018):166-173. |
入库方式： OAI收割
来源：上海药物研究所
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