Structural elucidation of a pectic polysaccharide from Fructus Mori and its bioactivity on intestinal bacteria strains
文献类型：期刊论文
| 作者 | Li, Saijuan1,2,3; Li, Meixia1,2; Yue, Han1,2,3; Zhou, Lishuang1,2,3; Huang, Lulin1,2; Du, Zhenyun1,2; Ding, Kan1,2,3
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| 刊名 | CARBOHYDRATE POLYMERS
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| 出版日期 | 2018-04-15 |
| 卷号 | 186页码:168-175 |
| 关键词 | Fructus Mori Polysaccharide Intestinal flora B. thetaiotaomicron |
| ISSN号 | 0144-8617 |
| DOI | 10.1016/j.carbpol.2018.01.026 |
| 文献子类 | Article |
| 英文摘要 | Many studies suggested that polysaccharides could impact on the gut microbiota. To discover new polysaccharides which influence intestinal beneficial bacteria, a pectin polysaccharide FMP-6-S2 with an average molecular weight of 86.83 kDa was purified from Fructus Mori. The monosaccharide residue analysis indicated that FMP-6-S2 was composed of rhamnose, galacturonic acid, galactose and arabinose in a molar ratio of 30.86: 24.78: 28.70: 15.61. The backbone of FMP-6-S2 contained 1, 4-linked alpha-GalpA and 1, 2-linked alpha-Rhap with branches substituted at C-4 position of rhamnose. The branches were composed of 1, 4-linked beta-Galp, terminal (T) - and 1, 3, 6-linked beta-Galp, T-and 1, 5-linked alpha-Araf. Bioactivity test results suggested that FMP-6-S2 and its degraded product could promote growth of intestinal bacteria, B. thetaiotaomicron, which is a dominate strain in the gut of human to benefit intestinal mucosa. These results suggested that FMP-6-S2 and its degraded product might improve human wellness by modulating B. thetaiotaomicron. |
| WOS关键词 | CHRYSANTHEMUM-MORIFOLIUM FLOWERS ; HUMAN GUT SYMBIONT ; BACTEROIDES-THETAIOTAOMICRON ; MULBERRY FRUIT ; ANTIOXIDANT ACTIVITY ; IN-VITRO ; ALBA L. ; MICROBIOTA ; GROWTH ; METABOLISM |
| 资助项目 | State Key Program of National Natural Science Foundation of China[31230022] ; New Drug Creation and Manufacturing Program[2017ZX09305-003] ; Ministry of Science and Technology, the People Republic of China[00000000] ; Program of Shanghai Subject Chief Scientist[16XD1404500] |
| WOS研究方向 | Chemistry ; Polymer Science |
| 语种 | 英语 |
| WOS记录号 | WOS:000426360800019 |
| 出版者 | ELSEVIER SCI LTD |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/279801]  |
| 专题 | 药理学第三研究室 |
| 通讯作者 | Li, Meixia; Ding, Kan |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, Key Lab Receptor Res, Glycochem & Glycobiol Lab, 555 Zu Chong Zhi Rd, Shanghai 201203, Peoples R China; 2.Univ Chinese Acad Sci, 19A Yuquan Rd, Beijing 100049, Peoples R China 3.Zunyi Med Univ, Sch Pharm, 201 Dalian Rd, Zunyi 563003, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Li, Saijuan,Li, Meixia,Yue, Han,et al. Structural elucidation of a pectic polysaccharide from Fructus Mori and its bioactivity on intestinal bacteria strains[J]. CARBOHYDRATE POLYMERS,2018,186:168-175. |
| APA | Li, Saijuan.,Li, Meixia.,Yue, Han.,Zhou, Lishuang.,Huang, Lulin.,...&Ding, Kan.(2018).Structural elucidation of a pectic polysaccharide from Fructus Mori and its bioactivity on intestinal bacteria strains.CARBOHYDRATE POLYMERS,186,168-175. |
| MLA | Li, Saijuan,et al."Structural elucidation of a pectic polysaccharide from Fructus Mori and its bioactivity on intestinal bacteria strains".CARBOHYDRATE POLYMERS 186(2018):168-175. |
入库方式： OAI收割
来源：上海药物研究所
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