Chemoenzymatically synthesized GM3 analogues as potential therapeutic agents to recover nervous functionality after injury by inducing neurite outgrowth
文献类型：期刊论文
| 作者 | Zheng, Changping1; Qu, Huanhuan4; Liao, Wenfeng4; Bavaro, Teodora2; Terreni, Marco2; Sollogoub, Matthieu1; Ding, Kan4 ; Zhang, Yongmin1,3
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| 刊名 | EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
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| 出版日期 | 2018-02-25 |
| 卷号 | 146页码:613-620 |
| 关键词 | Ganglioside GM3 Chemoenzymatic synthesis PC12 cells Neurite outgrowth |
| ISSN号 | 0223-5234 |
| DOI | 10.1016/j.ejmech.2018.01.079 |
| 文献子类 | Article |
| 英文摘要 | Ganglioside GM3 is implicated in a variety of physiological and pathological processes. Due to GM3 exposes on the outer surface of cell membranes, it is strongly associated with cell adhesion, motility and differentiation. Neurite outgrowth is a key process in the development of functional neuronal circuits and regeneration of the nervous system after injury. In the present study, we used enzymatic hydrolysis and chemical synthesis to obtain novel galactose containing GM3 analogues. By enzymatic hydrolysis to prepare GM3 building block, we can avoid multiple chemical procedures. Next, we employed the PC12 cells as a model to evaluate the effects of GM3 analogues on neurite outgrowth with or without NGF induction, The biological tests showed that GM3 analogues could induce neurite outgrowth, which provides the valuable sights for potential nervous system treatment after injury. (C) 2018 Elsevier Masson SAS. All rights reserved. |
| WOS关键词 | GROWTH-FACTOR ; GLYCOSPHINGOLIPIDS ; DIFFERENTIATION ; NEURITOGENESIS ; SPHINGOSINES ; SIALYLATION ; CELLS |
| 资助项目 | China Scholarship Council (CSC)[00000000] ; Centre National de la Recherche Scientifique (CNRS)[00000000] ; Sorbonne Universite in France[00000000] ; National Natural Science Foundation of China (NSFC)[21402224] ; Shanghai Science and Technology Development Funds[14YF1407800] |
| WOS研究方向 | Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000427310700049 |
| 出版者 | ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/279889]  |
| 专题 | 药理学第三研究室 |
| 通讯作者 | Qu, Huanhuan; Ding, Kan; Zhang, Yongmin |
| 作者单位 | 1.Sorbonne Univ, CNRS, UMR 8232, IPCM, 4 Pl Jussieu, F-75005 Paris, France; 2.Univ Pavia, Drug Sci Dept, Viale Taramelli 12, I-27100 Pavia, Italy 3.Jianghan Univ, Inst Interdisciplinary Res, Wuhan 430056, Hubei, Peoples R China; 4.Chinese Acad Sci, Shanghai Inst Mat Med, Key Lab Receptor Res, Glycochem & Glycobiol Lab, 555 Zu Chong Zhi Rd, Shanghai 201203, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Zheng, Changping,Qu, Huanhuan,Liao, Wenfeng,et al. Chemoenzymatically synthesized GM3 analogues as potential therapeutic agents to recover nervous functionality after injury by inducing neurite outgrowth[J]. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY,2018,146:613-620. |
| APA | Zheng, Changping.,Qu, Huanhuan.,Liao, Wenfeng.,Bavaro, Teodora.,Terreni, Marco.,...&Zhang, Yongmin.(2018).Chemoenzymatically synthesized GM3 analogues as potential therapeutic agents to recover nervous functionality after injury by inducing neurite outgrowth.EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY,146,613-620. |
| MLA | Zheng, Changping,et al."Chemoenzymatically synthesized GM3 analogues as potential therapeutic agents to recover nervous functionality after injury by inducing neurite outgrowth".EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY 146(2018):613-620. |
入库方式： OAI收割
来源：上海药物研究所
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