Sodiation-based in-source collision for profiling of pyranocoumarins in Radix Peucedani (Qianhu): utility of sodium adducts' stability with in-source collision
文献类型:期刊论文
作者 | Yang, W.3; Li, Y.3; Kang, C.3; Zhao, H.3; Xiang, L.3; Li, C.2,3; Wang, Q.1 |
刊名 | JOURNAL OF MASS SPECTROMETRY |
出版日期 | 2017-03 |
卷号 | 52期号:3页码:152-164 |
ISSN号 | 1076-5174 |
关键词 | sodium adducts in-source collision LC-ESI-MS pyranocoumarins Radix Peucedani |
DOI | 10.1002/jms.3913 |
文献子类 | Article |
英文摘要 | Full scan mode of liquid chromatography-mass spectrometry equipped with an electrospray ionization source offers a chance on global detection of complicated components; however, the scan mode carries significant challenges in rapidly capturing information of analysts. Sodiation-based in-source collision was proposed here, as a technique for rapid detecting untargeted analytes in full scan analysis, whichwas based on the stability of sodium adducts and the nonselectivity of in-source collision. Then the technique was applied to profile of angular-type pyranocoumarins (APs) in Radix Peucedani, with full scan analysis performed at two specific in-source collision energy: a high energy 50 V that is tolerated by the sodium adducts of APs, and a low energy 10 V, at which abundant adducts were offered. The spectra list of two average mass spectra was exported, and stable ions were selected based on the intensity ratio of standards at the two collision energy. Then 27 plausible [M+Na](+) m/z values of APs were acquired after filtering the fragmention and isotope ions and validating with [M+NH4](+). Eighty-two APs finally were tentatively identified based on their accurate spectral data of MSn, fragmentation rules, and elution order regardless of their absolute configuration, which included 25 reported APs from Peucedanum praeruptorum Dunn. The technique provided a novel application of sodium adduct in qualitative analysis. And it was valuable for rapidly capturing information of analytes in full scan analysis, not only for APs but also for other compounds that could form sodium adducts. Copyright (C) 2017 John Wiley & Sons, Ltd. |
WOS关键词 | FLIGHT MASS-SPECTROMETRY ; ANGULAR-TYPE PYRANOCOUMARINS ; PRAERUPTORUM DUNN ; INDUCED DISSOCIATION ; PANAX-NOTOGINSENG ; CHROMATOGRAPHY ; IDENTIFICATION ; ACIDS ; COUMARINS ; COMPONENTS |
资助项目 | Basic Scientific Research Business Expenses of China Academy of Chinese Medical Sciences[Zz2014044] ; Basic Scientific Research Business Expenses of China Academy of Chinese Medical Sciences[Zz2014034] ; National Science and Technology[2014ZX09201022] ; National Science and Technology[2015ZX09501004] |
WOS研究方向 | Biochemistry & Molecular Biology ; Chemistry ; Spectroscopy |
语种 | 英语 |
出版者 | WILEY |
WOS记录号 | WOS:000398039700004 |
源URL | [http://119.78.100.183/handle/2S10ELR8/272756] |
专题 | 上海药物代谢研究中心 科研与新药推进处 |
通讯作者 | Yang, W.; Wang, Q. |
作者单位 | 1.Hebei Med Univ, Sch Pharm, 361 East Zhongshan Rd, Shijiazhuang 050017, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Mat Med, Lab DMPK Res Herbal Med, 501 Haike Rd,Zhangjiang Hitech Pk, Shanghai 201203, Peoples R China; 3.China Acad Chinese Med Sci, Inst Chinese Mat Med, Ctr DMPK Res Herbal Med, 16 Nanxiaojie,Dongzhimennei Ave, Beijing 100700, Peoples R China; |
推荐引用方式 GB/T 7714 | Yang, W.,Li, Y.,Kang, C.,et al. Sodiation-based in-source collision for profiling of pyranocoumarins in Radix Peucedani (Qianhu): utility of sodium adducts' stability with in-source collision[J]. JOURNAL OF MASS SPECTROMETRY,2017,52(3):152-164. |
APA | Yang, W..,Li, Y..,Kang, C..,Zhao, H..,Xiang, L..,...&Wang, Q..(2017).Sodiation-based in-source collision for profiling of pyranocoumarins in Radix Peucedani (Qianhu): utility of sodium adducts' stability with in-source collision.JOURNAL OF MASS SPECTROMETRY,52(3),152-164. |
MLA | Yang, W.,et al."Sodiation-based in-source collision for profiling of pyranocoumarins in Radix Peucedani (Qianhu): utility of sodium adducts' stability with in-source collision".JOURNAL OF MASS SPECTROMETRY 52.3(2017):152-164. |
入库方式: OAI收割
来源:上海药物研究所
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