Bioavailability of clarithromycin cyclodextrin ternary complexes upon oral administration to healthy beagle dogs
文献类型：期刊论文
| 作者 | Zhang, Xiangrong1; Zou, Meijuan1; Li, Sanming1; Chen, Xiaoyan2 ; Zhong, Dafang2
|
| 刊名 | DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY
 |
| 出版日期 | 2008 |
| 卷号 | 34期号:10页码:1048-1053 |
| 关键词 | clarithromycin ternary inclusion complexes bioavailability |
| ISSN号 | 0363-9045 |
| DOI | 10.1080/03639040801937474 |
| 文献子类 | Article |
| 英文摘要 | The dissolution profiles of clarithromycin (CLM) and its beta-cyclodextrin-citric acid ternary complexes (CTC) were examined. CTC showed an enhanced dissolution rate in pH 6.8 phosphate buffers. The relative bioavailability was evaluated by comparing area under the plasma concentration-time curve (AUC) of the pure CLM with that of its cyclodextrin-citric acid ternary complexes those were filled into hard gelatin capsules. To compare the pharmacokinetic behavior, both plasma levels of parent compound and the active metabolite 14-OH-CLM concentrations were estimated. The relative bioavailability value as the ratios of CLM of mean total AUC for CTC relative to CLM was 120.3%. The relative bioavailability value as the ratios of 14-OH CLM of mean total AUC for CTC relative to CLM was 95.3%. The results suggest that the absorption of CTC in beagle dogs was slightly improved because of the enhanced dissolution rate of CTC at pH 6.8. |
| WOS关键词 | DRUGS |
| 资助项目 | 863 Program of China[2003AA2Z347C] |
| WOS研究方向 | Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000259622700004 |
| 出版者 | INFORMA HEALTHCARE |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/273018]  |
| 专题 | 上海药物代谢研究中心 |
| 通讯作者 | Zhong, Dafang |
| 作者单位 | 1.Shenyang Pharmaceut Univ, Coll Pharm, Shenyang, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Zhang, Xiangrong,Zou, Meijuan,Li, Sanming,et al. Bioavailability of clarithromycin cyclodextrin ternary complexes upon oral administration to healthy beagle dogs[J]. DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY,2008,34(10):1048-1053. |
| APA | Zhang, Xiangrong,Zou, Meijuan,Li, Sanming,Chen, Xiaoyan,&Zhong, Dafang.(2008).Bioavailability of clarithromycin cyclodextrin ternary complexes upon oral administration to healthy beagle dogs.DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY,34(10),1048-1053. |
| MLA | Zhang, Xiangrong,et al."Bioavailability of clarithromycin cyclodextrin ternary complexes upon oral administration to healthy beagle dogs".DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY 34.10(2008):1048-1053. |
入库方式： OAI收割
来源：上海药物研究所
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