Influence of omeprazole on pharmacokinetics of domperidone given as free base and maleate salt in healthy Chinese patients
文献类型：期刊论文
| 作者 | Zhang, Yi-fan ; Chen, Xiao-yan; Dai, Xiao-jian; Zhang, Yi-ni; Liu, Qi-zhi; Yu, Hua-ling; Zhong, Da-fang
|
| 刊名 | ACTA PHARMACOLOGICA SINICA
 |
| 出版日期 | 2007-08 |
| 卷号 | 28期号:8页码:1243-1246 |
| 关键词 | domperidone omeprazole maleate salt free base pharmacokinetics |
| ISSN号 | 1671-4083 |
| DOI | 10.1111/j.1745-7254.2007.00596.x |
| 文献子类 | Article |
| 英文摘要 | Aim: To investigate the influence of omeprazole on the pharmacokinetics of domperidone given as free base and maleate salt. Methods: An open, randomized, 2-period crossover study with a washout period of 7 d was conducted in 10 healthy Chinese, male patients. In each study period, the patients were administered a single oral dose of 10 mg domperidone as free base or maleate salt on d 1, 20 mg omeprazole twice daily on d 2 and 3, and once on d 4. A single dose of 10 mg domperidone as free base or maleate salt was taken at 4 h after administration of omeprazole on d 4. Plasma samples were collected on d 1 and 4 after the administration of domperidone, and the plasma concentrations of domperidone were determined by a sensitive liquid chromatography-tandem mass spectrometry method. Results: For free-base domperidone, pretreatment with omeprazole resulted in a 16% decrease in maximum concentration (C-max), compared with administration alone (P < 0.05). However, for maleate salt, with the exception of an increase in t(1/2), no pharmacokinetic parameters were significantly changed. When the free base and maleate salt were administered alone, no differences were found in any parameters between the 2 formulations. In contrast, when they were administered in the presence of omeprazole, the C-max of domperidone given as free base was lower (25.9%) than that given as maleate salt (P < 0.05). Conclusion: Pretreatment of omeprazole does not affect the absorption of domperidone maleate, but leads to a moderately decreased rate of absorption of the free base. |
| WOS关键词 | GASTROESOPHAGEAL-REFLUX DISEASE ; INTRAGASTRIC PH ; PANTOPRAZOLE |
| WOS研究方向 | Chemistry ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| CSCD记录号 | CSCD:3088160 |
| WOS记录号 | WOS:000248512000022 |
| 出版者 | BLACKWELL PUBLISHING |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/273182]  |
| 专题 | 上海药物代谢研究中心 |
| 通讯作者 | Zhong, Da-fang |
| 作者单位 | 1.Beijing Hanmi Pharm, Beijing 101312, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, Yi-fan,Chen, Xiao-yan,Dai, Xiao-jian,et al. Influence of omeprazole on pharmacokinetics of domperidone given as free base and maleate salt in healthy Chinese patients[J]. ACTA PHARMACOLOGICA SINICA,2007,28(8):1243-1246. |
| APA | Zhang, Yi-fan.,Chen, Xiao-yan.,Dai, Xiao-jian.,Zhang, Yi-ni.,Liu, Qi-zhi.,...&Zhong, Da-fang.(2007).Influence of omeprazole on pharmacokinetics of domperidone given as free base and maleate salt in healthy Chinese patients.ACTA PHARMACOLOGICA SINICA,28(8),1243-1246. |
| MLA | Zhang, Yi-fan,et al."Influence of omeprazole on pharmacokinetics of domperidone given as free base and maleate salt in healthy Chinese patients".ACTA PHARMACOLOGICA SINICA 28.8(2007):1243-1246. |
入库方式： OAI收割
来源：上海药物研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。