Determination of meloxicam in human plasma by liquid chromatography-tandem mass spectrometry following transdermal administration
文献类型：期刊论文
| 作者 | Yuan, Yue; Chen, Xiaoyan ; Zhong, Dafang
|
| 刊名 | JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES
 |
| 出版日期 | 2007-06-01 |
| 卷号 | 852期号:1-2页码:650-654 |
| 关键词 | meloxicam LC-MS-MS pharmacokinetics transdermal |
| ISSN号 | 1570-0232 |
| DOI | 10.1016/j.jchromb.2007.01.036 |
| 文献子类 | Article |
| 英文摘要 | A highly sensitive and selective liquid chromatography-tandem mass spectrometry (LC-MS-MS) method was developed to determine meloxicam of low concentration in human plasma. After a simple sample preparation procedure by one-step protein precipitation with methanol, meloxicam and the internal standard piroxicam were chromatographed on a Zorbax SB C-18 column. The mobile phase consisted of acetonitrile-water-formic acid (80:20:0.2, v/v/v). Detection was performed on a triple quadrupole tandem mass spectrometer by selected reaction monitoring (SRM) mode via eletrospray ionization (ESI) source. The method had a lower limit of quantification of 0.10 ng/ml. The calibration curve was demonstrated to be linear over the concentration range of 0.10-50.0 ng/ml. The assay was specific, accurate (percentage deviations from nominal concentrations were within 2.5%), precise (intra- and inter-day relative standard deviation (R.S.D.) < 7%). The validated method was successfully applied to the determination of meloxicam in human plasma collected up to 180 h after a transdermal administration of 30 mg meloxicam for evaluation of the pharmacokinetics. (c) 2007 Elsevier B.V. All rights reserved. |
| WOS关键词 | PHARMACOKINETICS ; DICLOFENAC ; PIROXICAM |
| WOS研究方向 | Biochemistry & Molecular Biology ; Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000247286700091 |
| 出版者 | ELSEVIER SCIENCE BV |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/273246]  |
| 专题 | 上海药物代谢研究中心 |
| 通讯作者 | Zhong, Dafang |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China 2.Shenyang Pharmaceut Univ, Sch Pharm, Shenyang 110016, Peoples R China |
| 推荐引用方式 GB/T 7714 | Yuan, Yue,Chen, Xiaoyan,Zhong, Dafang. Determination of meloxicam in human plasma by liquid chromatography-tandem mass spectrometry following transdermal administration[J]. JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES,2007,852(1-2):650-654. |
| APA | Yuan, Yue,Chen, Xiaoyan,&Zhong, Dafang.(2007).Determination of meloxicam in human plasma by liquid chromatography-tandem mass spectrometry following transdermal administration.JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES,852(1-2),650-654. |
| MLA | Yuan, Yue,et al."Determination of meloxicam in human plasma by liquid chromatography-tandem mass spectrometry following transdermal administration".JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES 852.1-2(2007):650-654. |
入库方式： OAI收割
来源：上海药物研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。