Physicochemical properties and evaluation of microemulsion systems for transdermal delivery of meloxicam
文献类型：期刊论文
| 作者 | Yuan Yue; Li San-ming; Yu Li-min; Deng Pan; Zhong Da-fang
|
| 刊名 | CHEMICAL RESEARCH IN CHINESE UNIVERSITIES
 |
| 出版日期 | 2007-01 |
| 卷号 | 23期号:1页码:81-86 |
| 关键词 | microemulsion physicochemical property transdermal delivery meloxicam polyoxyethylene sorbitan trioleate |
| ISSN号 | 1005-9040 |
| DOI | 10.1016/S1005-9040(07)60016-6 |
| 文献子类 | Article |
| 英文摘要 | Microemulsion systems, composed of water, isopropyl myristate (IPM), polyoxyethylene sorbitan trioleate (Tween 85), and ethanol, were investigated as transdermal drug delivery vehicles for a lipophilic model drug (meloxicam). The purpose of this study was to investigate the physicochemical properties of the tested microemulsion and to find the correlation between the physicochemical properties and the skin permeation rate of the microemulsion. Pseudo-ternary phase diagram of the investigated system at a constant surfactant/cosurfactant mass ratio(K-m = 1: 1) was constructed by titration at 20 degrees C, and the five formulations were selected for further research in the o/w microemulsion domains. The values of electrical conductivity and viscosity showed that the selected systems were bicontinuous or non-spherical o/w microemulsion, and the electrical conductivity and viscosity were increased with increasing the content of water. These results suggest that the optimum formulation of microemulsion, containing 0.375 meloxicam, 5% isopropyl myristate, 25% Tween 85, 25% ethanol, and water, showed the maximum permeation rate. It had a high electrical conductivity, small droplet size, and proper viscocity. |
| WOS关键词 | DRUG ; KETOPROFEN |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000244006800016 |
| 出版者 | HIGHER EDUCATION PRESS |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/273368]  |
| 专题 | 上海药物代谢研究中心 |
| 通讯作者 | Zhong Da-fang |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, Ctr Drug Metab & Pharmacokinet Res, Shanghai 201203, Peoples R China 2.Shenyang Pharmaceut Univ, Sch Pharm, Shenyang 110016, Peoples R China |
| 推荐引用方式 GB/T 7714 | Yuan Yue,Li San-ming,Yu Li-min,et al. Physicochemical properties and evaluation of microemulsion systems for transdermal delivery of meloxicam[J]. CHEMICAL RESEARCH IN CHINESE UNIVERSITIES,2007,23(1):81-86. |
| APA | Yuan Yue,Li San-ming,Yu Li-min,Deng Pan,&Zhong Da-fang.(2007).Physicochemical properties and evaluation of microemulsion systems for transdermal delivery of meloxicam.CHEMICAL RESEARCH IN CHINESE UNIVERSITIES,23(1),81-86. |
| MLA | Yuan Yue,et al."Physicochemical properties and evaluation of microemulsion systems for transdermal delivery of meloxicam".CHEMICAL RESEARCH IN CHINESE UNIVERSITIES 23.1(2007):81-86. |
入库方式： OAI收割
来源：上海药物研究所
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