Investigation of microemulsion system for transdermal delivery of meloxicam
文献类型：期刊论文
| 作者 | Yuan, Yue; Li, San-ming; Mo, Feng-kui; Zhong, Da-fang
|
| 刊名 | INTERNATIONAL JOURNAL OF PHARMACEUTICS
 |
| 出版日期 | 2006-09-14 |
| 卷号 | 321期号:1-2页码:117-123 |
| 关键词 | meloxicam microemulsion Transdermal IPM phase diagram skin permeability |
| ISSN号 | 0378-5173 |
| DOI | 10.1016/j.ijpharm.2006.06.021 |
| 文献子类 | Article |
| 英文摘要 | A new oil-in-water microemulsion containing 0.375% meloxicam was developed in order to improve the skin permeability of meloxicam. Among various surfactants and cosurfactants investigated in the microemulsion system, polyoxyethylene sorbitan trioleate (Tween 85) showed excellent solubility and ethanol expressed skin permeation enhancing effect for meloxicam. The microemulsion existence ranges were defined through the construction of the speudo-temary phase diagram. The effect of the content of isopropyl myristate (IPM) and the effect of the mass ratio of the surfactant/cosurfactant (Km) on skin permeation of meloxicam were evaluated with excised rat skins. The optimum formulation with the highest skin permeation rate (5.40 mu g/cm(2)/h) consisted of 0.375% meloxicam, 5% IPM, 50% Tween 85/ethanol (1:1) and water. (c) 2006 Elsevier B.V. All rights reserved. |
| WOS关键词 | DRUG-DELIVERY ; CLINICAL PHARMACOKINETICS ; TOPICAL DELIVERY ; FORMULATION ; ABSORPTION ; PIROXICAM |
| WOS研究方向 | Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000240612200016 |
| 出版者 | ELSEVIER SCIENCE BV |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/273492]  |
| 专题 | 上海药物代谢研究中心 |
| 通讯作者 | Zhong, Da-fang |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, Ctr Drug Metab & Pharmacokinet Res, Shanghai 201203, Peoples R China 2.Shenyang Pharmaceut Univ, Sch Pharm, Shenyang 110016, Peoples R China 3.Shenyang Pharmaceut Univ, Lab Drug Metab & Pharmacokinet, Shenyang 110016, Peoples R China |
| 推荐引用方式 GB/T 7714 | Yuan, Yue,Li, San-ming,Mo, Feng-kui,et al. Investigation of microemulsion system for transdermal delivery of meloxicam[J]. INTERNATIONAL JOURNAL OF PHARMACEUTICS,2006,321(1-2):117-123. |
| APA | Yuan, Yue,Li, San-ming,Mo, Feng-kui,&Zhong, Da-fang.(2006).Investigation of microemulsion system for transdermal delivery of meloxicam.INTERNATIONAL JOURNAL OF PHARMACEUTICS,321(1-2),117-123. |
| MLA | Yuan, Yue,et al."Investigation of microemulsion system for transdermal delivery of meloxicam".INTERNATIONAL JOURNAL OF PHARMACEUTICS 321.1-2(2006):117-123. |
入库方式： OAI收割
来源：上海药物研究所
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