Sensitive and rapid quantification of felodipine by high-performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS) and its pharmacokinetics in healthy Chinese volunteers
文献类型：期刊论文
| 作者 | Li Yan-yan; Yin Yi-zi; Sun Zhi-hui; Li Xin; Hu Li-gang; Li Peng-fei; Zhong Da-fang
|
| 刊名 | CHEMICAL RESEARCH IN CHINESE UNIVERSITIES
 |
| 出版日期 | 2006-07 |
| 卷号 | 22期号:4页码:479-483 |
| 关键词 | felodipine liquid chromatography-tandem mass-spectrometry pharmacokinetics |
| ISSN号 | 1005-9040 |
| DOI | 10.1016/S1005-9040(06)60146-3 |
| 文献子类 | Article |
| 英文摘要 | To investigate the pharmacokinetics of felodipine in the plasma of healthy Chinese volunteers, 30 healthy volunteers received a single oral dose of 5 mg of extended release felodipine tablets. The felodipine was extracted from the matrix with a liquid-liquid extract procedure and analyzed by high-performance liquid chromatography-tandem mass spectrometry in the multiple reaction monitoring(MRM) mode using an electrospray ion source with positive ion detection. The method was validated over a felodipine concentration range of 0.05-10.00 ng/mL in human plasma. Its main pharmacokinetic parameters values were: rho(max) = ( 1.67 +/- 0.84) ng/mL, occurring at ( 3.93 +/- 2.49) h; the plasma elimination half-life: ( 23.08 +/- 9.48) h and the area under the plasma concentration versus time curve: (29.94 +/- 14.39) ng . h/mL. The validation results demonstrated that this method showed a satisfactory precision and accuracy across the calibration range. The procedure involved minimal drug administration, sample preparation, and a 2.5-min chromatographic run time. It was well suited to clinical studies of the drug involving large numbers of samples. |
| WOS关键词 | HUMAN PLASMA ; RELEASE FORMULATIONS ; METOPROLOL ; PROFILES |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000239983000017 |
| 出版者 | HIGHER EDUCATION PRESS |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/273549]  |
| 专题 | 上海药物代谢研究中心 |
| 通讯作者 | Zhong Da-fang |
| 作者单位 | 1.Jilin Univ, Res Ctr Drug Metab, Changchun 130021, Peoples R China 2.Jilin Univ, Hosp 1, Changchun 130021, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li Yan-yan,Yin Yi-zi,Sun Zhi-hui,et al. Sensitive and rapid quantification of felodipine by high-performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS) and its pharmacokinetics in healthy Chinese volunteers[J]. CHEMICAL RESEARCH IN CHINESE UNIVERSITIES,2006,22(4):479-483. |
| APA | Li Yan-yan.,Yin Yi-zi.,Sun Zhi-hui.,Li Xin.,Hu Li-gang.,...&Zhong Da-fang.(2006).Sensitive and rapid quantification of felodipine by high-performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS) and its pharmacokinetics in healthy Chinese volunteers.CHEMICAL RESEARCH IN CHINESE UNIVERSITIES,22(4),479-483. |
| MLA | Li Yan-yan,et al."Sensitive and rapid quantification of felodipine by high-performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS) and its pharmacokinetics in healthy Chinese volunteers".CHEMICAL RESEARCH IN CHINESE UNIVERSITIES 22.4(2006):479-483. |
入库方式： OAI收割
来源：上海药物研究所
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