Determination of zolmitriptan in human plasma by liquid chromatography-tandem mass spectrometry method: Application to a pharmacokinetic study
文献类型：期刊论文
| 作者 | Chen, XY ; Liu, D; Luan, Y; Jin, FD; Zhong, DF
|
| 刊名 | JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES
 |
| 出版日期 | 2006-02-17 |
| 卷号 | 832期号:1页码:30-35 |
| 关键词 | zolmitriptan triptan pharmacokinetics liquid chromatography-tandem mass spectrometry |
| ISSN号 | 1570-0232 |
| DOI | 10.1016/j.jchromb.2005.12.008 |
| 文献子类 | Article |
| 英文摘要 | A sensitive and selective liquid chromatography-tandem spectrometry method for the determination of zolmitriptan was developed and validated over the linearity range 0.05-30 ng/ml with 0.5 ml of plasma using diphenhydramine as the internal standard. Liquid-liquid extraction using a mixture of diethyl ether and dichloromethane was used to extract the drug and the internal standard from plasma. The mass spectrometer was operated under the selected reaction monitoring (SRM) mode using the atmospheric pressure chemical ionization (APCI) technique. The instrument parameters were optimized to obtain 3.0 min run time. The mobile phase consisted of acetonitrile-water-formic acid (70:30:0.5), at a flow rate of 0.5 ml/min. In positive mode, zolmitriptan produced a protonated precursor ion at m/z 288 and a corresponding product ion at m/z 58. And internal standard produced a protonated precursor ion at m/z 256 and a corresponding product ion at m/z 167. The inter- and intra-day precision (%R.S.D.) were less than 8.5% and accuracy (%error) was less than -2.5%. The method had a lower limit of quantification of 0.05 ng/ml for zolmitriptan, which offered increased sensitivity and selectivity of analysis, compared with existing methods. The method was successfully applied to a pharmacokinetic study of zolmitriptan after an oral administration of 5 mg zolmitriptan to 20 healthy volunteers. (c) 2005 Elsevier B.V. All rights reserved. |
| WOS关键词 | ANTIMIGRAINE COMPOUND ZOLMITRIPTAN ; ABSOLUTE BIOAVAILABILITY ; FLUORESCENCE DETECTION ; COULOMETRIC DETECTION ; MIGRAINE ; SUMATRIPTAN ; TRIPTANS ; RIZATRIPTAN ; VOLUNTEERS ; 311C90 |
| WOS研究方向 | Biochemistry & Molecular Biology ; Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000235769100005 |
| 出版者 | ELSEVIER SCIENCE BV |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/273666]  |
| 专题 | 上海药物代谢研究中心 |
| 通讯作者 | Zhong, DF |
| 作者单位 | 1.Shenyang Pharmaceut Univ, Lab Drug Metab & Pharmacokinet, Shenyang 110016, Peoples R China 2.Shenyang Ctr Dis Control & Prevent, Shenyang 110031, Peoples R China 3.Chinese Acad Sci, Shanghai Inst Mat Med, Ctr Drug Metab & Pharmacokinet, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Chen, XY,Liu, D,Luan, Y,et al. Determination of zolmitriptan in human plasma by liquid chromatography-tandem mass spectrometry method: Application to a pharmacokinetic study[J]. JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES,2006,832(1):30-35. |
| APA | Chen, XY,Liu, D,Luan, Y,Jin, FD,&Zhong, DF.(2006).Determination of zolmitriptan in human plasma by liquid chromatography-tandem mass spectrometry method: Application to a pharmacokinetic study.JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES,832(1),30-35. |
| MLA | Chen, XY,et al."Determination of zolmitriptan in human plasma by liquid chromatography-tandem mass spectrometry method: Application to a pharmacokinetic study".JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES 832.1(2006):30-35. |
入库方式： OAI收割
来源：上海药物研究所
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