Pharmacokinetics of telmisartan in healthy chinese subjects after oral administration of two dosage levels
文献类型：期刊论文
| 作者 | Zhang, Peng; Zhang, Yifan ; Chen, Xiaoyan; Li, Rongqin; Yin, Jian; Zhong, Dafang
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| 刊名 | ARZNEIMITTEL-FORSCHUNG-DRUG RESEARCH
 |
| 出版日期 | 2006 |
| 卷号 | 56期号:8页码:569-573 |
| 关键词 | angiotensin II receptor antagonist antihypertensive agent CAS 144701-48-4 MicardisPlus((R)) Telmisartan, clinical pharmacoldnetics, dose-related analysis |
| ISSN号 | 0004-4172 |
| 文献子类 | Article |
| 英文摘要 | To study the pharmacokinetics of telmisartan in healthy Chinese male subjects after oral administration of two dosage levels, 36 healthy subjects were divided into two groups and given a single oral dose of 40 or 80 mg telmisartan (CAS 144701-48-4, MicardisPlus((R))). A sensitive liquid chromatography-tandem mass spectrometry method (LC-MS-MS) was used for the determination of telmisartan in plasma. Both, a non-compartmental and compartmental method were used for analysis of parameters of kinetics. The main pharmacokinetic parameters of the 40 mg and 80 mg regimen group were as follows: t(max) (1.76 +/- 1.75) h, (1.56 +/- 1.09) h, C-max (163.2 +/- 128.4) ng/mL, (905.7 +/- 583.4) ng/mL, t(1/2) (23.6 +/- 10.8) h, (23.0 +/- 6.4) h, AUC(0-t) (1456 +/- 1072) ng(.)h/mL, (6759 +/- 3754) ng(.)h/mL, AUC(0-infinity) (1611 +/- 1180) ng(.)h/mL, (7588 +/- 4661) ng(.)h/mL, respectively. After dose normalization, there was significant difference for main pharmacokinetic parameters C-max, AUC(0-t) and AUC(0-infinity). between two dosage level groups. The plasma concentration-time profile of telmisartan was characterized by a high degree of inter-individual variability and the disposition of telmisartan in healthy Chinese subjects was dose-dependent. The pharmacokinetic parameters C-max and AUC(0-infinity) of the 80 mg regimen group increased to about 5-fold compared to that of the 40 mg regimen group, but there was no significant difference for t(max) and t(1/2) between the two dose groups. |
| WOS关键词 | RAPID-DETERMINATION ; SERUM |
| WOS研究方向 | Pharmacology & Pharmacy ; Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000240760500001 |
| 出版者 | ECV-EDITIO CANTOR VERLAG MEDIZIN NATURWISSENSCHAFTEN |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/273695]  |
| 专题 | 上海药物代谢研究中心 |
| 通讯作者 | Zhong, Dafang |
| 作者单位 | 1.Shenyang Pharmaceut Univ, Lab Drug Metab & Pharmacokinet, Shenyang, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China 3.Peoples Hosp Liaoning Prov, Shenyang, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, Peng,Zhang, Yifan,Chen, Xiaoyan,et al. Pharmacokinetics of telmisartan in healthy chinese subjects after oral administration of two dosage levels[J]. ARZNEIMITTEL-FORSCHUNG-DRUG RESEARCH,2006,56(8):569-573. |
| APA | Zhang, Peng,Zhang, Yifan,Chen, Xiaoyan,Li, Rongqin,Yin, Jian,&Zhong, Dafang.(2006).Pharmacokinetics of telmisartan in healthy chinese subjects after oral administration of two dosage levels.ARZNEIMITTEL-FORSCHUNG-DRUG RESEARCH,56(8),569-573. |
| MLA | Zhang, Peng,et al."Pharmacokinetics of telmisartan in healthy chinese subjects after oral administration of two dosage levels".ARZNEIMITTEL-FORSCHUNG-DRUG RESEARCH 56.8(2006):569-573. |
入库方式： OAI收割
来源：上海药物研究所
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