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Targeting Obesity for the Prevention of Chronic Cardiovascular Disease Through Gut Microbiota-Herb Interactions: An Opportunity for Traditional Herbs

文献类型：期刊论文

作者Chen, Feng2; Jiang, Jun2; Tian, Dan-Dan3; Wen, Qi2; Li, Yong-Hui2; Zhang, Jun-Qing2; Cheng, Chen4; Wang, Tengfei1
刊名CURRENT PHARMACEUTICAL DESIGN
出版日期2017
卷号23期号:8页码:1142-1152
关键词Obesity cardiovascular disease gut microbiota oral availability conundrum gut microbiota-herb interactions microbiota availability
ISSN号1381-6128
DOI10.2174/1381612822666161014115724
文献子类Review
英文摘要Cardiovascular disease still remains the primary cause of death worldwide and obesity is becoming recognized as one of the most critical contributing risk factors. The increased prevalence of obesity casts a cloud over the global health and the whole societies and will still be burdened in the future. Therefore, prevention and therapy of obesity is a beneficial strategy for the prevention of chronic cardiovascular disease. Numerous studies have demonstrated that gut microbiota takes part in human health and disease including obesity. Traditional herbs hold great potential to improve people's health and wellness, particularly in the area of chronic inflammatory diseases although the mechanisms of action remain poorly understood. Emerging explorations of gut microbiotaherb interactions provide a potential to revolutionize the way we view herbal therapeutics. This review summarizes the experimental studies performed on animals and humans regarding the gut microbiota-herb interactions targeting obesity. This review also discusses the opportunity of herbs with potent activities but low oral bioavailability conundrum for prevention and therapy for obesity and related cardiovascular disease.
WOS关键词CHAIN FATTY-ACIDS ; BOFU-TSUSHO-SAN ; DIET-INDUCED OBESITY ; GERM-FREE MICE ; MECHANISMS LINKING OBESITY ; ACTIVATED PROTEIN-KINASE ; DRUG-PROCESSING GENES ; SCHISANDRA-CHINENSIS ; METABOLIC SYNDROME ; ENDOTHELIAL-CELLS
资助项目National Natural Science Foundation of China[81460629] ; National Natural Science Foundation of China[81560738] ; National Natural Science Foundation of China[81560721]
WOS研究方向Pharmacology & Pharmacy
语种英语
WOS记录号WOS:000400515000003
出版者BENTHAM SCIENCE PUBL LTD
源URL[http://119.78.100.183/handle/2S10ELR8/275721]  
专题上海药物代谢研究中心
通讯作者Jiang, Jun; Wang, Tengfei
作者单位1.Univ Tennessee, Hlth Sci Ctr, Dept Pharmacol, Memphis, TN 38163 USA
2.Hainan Med Coll, Sch Pharm, Hainan Prov Key Lab R&D Trop Herbs, Haikou, Peoples R China;
3.Univ Hong Kong, LKS Fac Med, Sch Chinese Med, Hong Kong, Hong Kong, Peoples R China;
4.Chinese Acad Sci, Shanghai Inst Mat Med, Lab DMPK Res Herbal Med, Shanghai, Peoples R China;
推荐引用方式
GB/T 7714		 Chen, Feng,Jiang, Jun,Tian, Dan-Dan,et al. Targeting Obesity for the Prevention of Chronic Cardiovascular Disease Through Gut Microbiota-Herb Interactions: An Opportunity for Traditional Herbs[J]. CURRENT PHARMACEUTICAL DESIGN,2017,23(8):1142-1152.
APA Chen, Feng.,Jiang, Jun.,Tian, Dan-Dan.,Wen, Qi.,Li, Yong-Hui.,...&Wang, Tengfei.(2017).Targeting Obesity for the Prevention of Chronic Cardiovascular Disease Through Gut Microbiota-Herb Interactions: An Opportunity for Traditional Herbs.CURRENT PHARMACEUTICAL DESIGN,23(8),1142-1152.
MLA Chen, Feng,et al."Targeting Obesity for the Prevention of Chronic Cardiovascular Disease Through Gut Microbiota-Herb Interactions: An Opportunity for Traditional Herbs".CURRENT PHARMACEUTICAL DESIGN 23.8(2017):1142-1152.

入库方式： OAI收割

来源：上海药物研究所

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